引用本文:
Qing lie Zhao, Yan Song, Hong Gang Hu, Shi Chong Yu, Qiu Ye Wu. Design, synthesis and antifungal activity of novel triazole derivatives[J]. Chinese Chemical Letters,
2007, 18(6): 670-672.
doi:
10.1016/j.cclet.2007.04.019
Citation: Qing lie Zhao, Yan Song, Hong Gang Hu, Shi Chong Yu, Qiu Ye Wu. Design, synthesis and antifungal activity of novel triazole derivatives[J]. Chinese Chemical Letters, 2007, 18(6): 670-672. doi: 10.1016/j.cclet.2007.04.019
Citation: Qing lie Zhao, Yan Song, Hong Gang Hu, Shi Chong Yu, Qiu Ye Wu. Design, synthesis and antifungal activity of novel triazole derivatives[J]. Chinese Chemical Letters, 2007, 18(6): 670-672. doi: 10.1016/j.cclet.2007.04.019
Design, synthesis and antifungal activity of novel triazole derivatives
摘要:
Twenty-three 1-(1H-1, 2, 4-triazole-1-yl)-2-(2, 4-difluorophenyl)-3-(N-cycloproyl-N-substituted-amino)-2-propanols were designed and synthesized on the basis of the active site of lanosterol 14α-demethylase.In vitro antifungal activities showed that some of the title compounds had higher antifungal activity and broader antifungal spectrum than fluconazole.
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关键词:
- Antifungal
- / Tiazole
- / Synthesis
English
Design, synthesis and antifungal activity of novel triazole derivatives
Abstract:
Twenty-three 1-(1H-1, 2, 4-triazole-1-yl)-2-(2, 4-difluorophenyl)-3-(N-cycloproyl-N-substituted-amino)-2-propanols were designed and synthesized on the basis of the active site of lanosterol 14α-demethylase.In vitro antifungal activities showed that some of the title compounds had higher antifungal activity and broader antifungal spectrum than fluconazole.
-
Key words:
- Antifungal
- / Tiazole
- / Synthesis
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