引用本文:
Ying ZHOU, Liang Ren ZHANG, Li He ZHANG. The Application of Allyl as a Protecting Group in the Preparation Of Dinucleoside Carbonate[J]. Chinese Chemical Letters,
1998, 9(9): 791-793.
Citation: Ying ZHOU, Liang Ren ZHANG, Li He ZHANG. The Application of Allyl as a Protecting Group in the Preparation Of Dinucleoside Carbonate[J]. Chinese Chemical Letters, 1998, 9(9): 791-793.
Citation: Ying ZHOU, Liang Ren ZHANG, Li He ZHANG. The Application of Allyl as a Protecting Group in the Preparation Of Dinucleoside Carbonate[J]. Chinese Chemical Letters, 1998, 9(9): 791-793.
The Application of Allyl as a Protecting Group in the Preparation Of Dinucleoside Carbonate
摘要:
Reaction of 5'-O-p-methoxytritylthymidine with 1,1'-carbonyl-diimidazole gave the 3'-O-carbonylimidazolide, which was condensed in high yield with 3'-0-protected thymidine to give a dinucleoside carbonate. In the synthesis of dinucleoside carbonate, allyl can be used as a good protecting group for 3'-hydroxyl of thymidine. The condition of deprotection will not affect the carbonate bridges.
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关键词:
- allyl
- / PdCl2
- / deprotection
- / dinucleoside carbonate
- / synthesis
English
The Application of Allyl as a Protecting Group in the Preparation Of Dinucleoside Carbonate
Abstract:
Reaction of 5'-O-p-methoxytritylthymidine with 1,1'-carbonyl-diimidazole gave the 3'-O-carbonylimidazolide, which was condensed in high yield with 3'-0-protected thymidine to give a dinucleoside carbonate. In the synthesis of dinucleoside carbonate, allyl can be used as a good protecting group for 3'-hydroxyl of thymidine. The condition of deprotection will not affect the carbonate bridges.
-
Key words:
- allyl
- / PdCl2
- / deprotection
- / dinucleoside carbonate
- / synthesis
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