引用本文:
Xing Yong Wang, Jing Nan Cui, Wei Min Ren, Feng Li, Chun Liang Lu, Xu Hong Qian. Baker's yeast mediated reduction of substituted acenaphthenequinones: Regio- and enantioselective preparation of mono-hydroxyacenaphthenones[J]. Chinese Chemical Letters,
2007, 18(6): 681-684.
doi:
10.1016/j.cclet.2007.04.022
Citation: Xing Yong Wang, Jing Nan Cui, Wei Min Ren, Feng Li, Chun Liang Lu, Xu Hong Qian. Baker's yeast mediated reduction of substituted acenaphthenequinones: Regio- and enantioselective preparation of mono-hydroxyacenaphthenones[J]. Chinese Chemical Letters, 2007, 18(6): 681-684. doi: 10.1016/j.cclet.2007.04.022

Citation: Xing Yong Wang, Jing Nan Cui, Wei Min Ren, Feng Li, Chun Liang Lu, Xu Hong Qian. Baker's yeast mediated reduction of substituted acenaphthenequinones: Regio- and enantioselective preparation of mono-hydroxyacenaphthenones[J]. Chinese Chemical Letters, 2007, 18(6): 681-684. doi: 10.1016/j.cclet.2007.04.022

Baker's yeast mediated reduction of substituted acenaphthenequinones: Regio- and enantioselective preparation of mono-hydroxyacenaphthenones
摘要:
Baker's yeast mediated reduction of acenaphthenequinone within 4-10 h afforded mono-hydroxyacenaphthenone mainly with low enantioselectivity, the substrate and mono-hydroxyacenaphthenone product almost converted to dihydroxyacenaphthene after 48 h.By control of the reaction time and in the presence of DMF as co-solvent, the reduction of 6-substituted acenaphthenequinones under vigorous agitation afforded the corresponding 2-hydroxyacenaphthenones in 24-84% yields with 10-93% ee.
English
Baker's yeast mediated reduction of substituted acenaphthenequinones: Regio- and enantioselective preparation of mono-hydroxyacenaphthenones
Abstract:
Baker's yeast mediated reduction of acenaphthenequinone within 4-10 h afforded mono-hydroxyacenaphthenone mainly with low enantioselectivity, the substrate and mono-hydroxyacenaphthenone product almost converted to dihydroxyacenaphthene after 48 h.By control of the reaction time and in the presence of DMF as co-solvent, the reduction of 6-substituted acenaphthenequinones under vigorous agitation afforded the corresponding 2-hydroxyacenaphthenones in 24-84% yields with 10-93% ee.
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Key words:
- Baker's yeast
- / Reduction
- / Regio- and enantioselectivity
- / Chiral hydroxyacenaphthenone

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