Polyphosphorous acid catalyzed cyclization in the synthesis of cryptolepine derivatives

Sheng Biao Wan Zhe Lin Liu Di Chen Qing Ping Dou Tao Jiang

引用本文: Sheng Biao Wan,  Zhe Lin Liu,  Di Chen,  Qing Ping Dou,  Tao Jiang. Polyphosphorous acid catalyzed cyclization in the synthesis of cryptolepine derivatives[J]. Chinese Chemical Letters, 2007, 18(10): 1178-1181. doi: 10.1016/j.cclet.2007.08.014 shu
Citation:  Sheng Biao Wan,  Zhe Lin Liu,  Di Chen,  Qing Ping Dou,  Tao Jiang. Polyphosphorous acid catalyzed cyclization in the synthesis of cryptolepine derivatives[J]. Chinese Chemical Letters, 2007, 18(10): 1178-1181. doi: 10.1016/j.cclet.2007.08.014 shu

Polyphosphorous acid catalyzed cyclization in the synthesis of cryptolepine derivatives

  • 基金项目:

    This work was supported by National Basic Research Program of China (973 Program)(No.2003CB71640).

摘要: 11-Oxo-10, 11-dihydroxy-5H-indolo[3, 2, b]quinoline 7-carboxylic acid was obtained specifically by polyphosphorous acid catalyzed cyclization with optimal reaction conditions. Biological assays showed that it potentially inhibits the proteasomal chymotrypsin-like activity in vitro and suppresses breast cancer cell growth.

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  • 收稿日期:  2007-04-25
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