引用本文:
Sheng Biao Wan, Zhe Lin Liu, Di Chen, Qing Ping Dou, Tao Jiang. Polyphosphorous acid catalyzed cyclization in the synthesis of cryptolepine derivatives[J]. Chinese Chemical Letters,
2007, 18(10): 1178-1181.
doi:
10.1016/j.cclet.2007.08.014
Citation: Sheng Biao Wan, Zhe Lin Liu, Di Chen, Qing Ping Dou, Tao Jiang. Polyphosphorous acid catalyzed cyclization in the synthesis of cryptolepine derivatives[J]. Chinese Chemical Letters, 2007, 18(10): 1178-1181. doi: 10.1016/j.cclet.2007.08.014

Citation: Sheng Biao Wan, Zhe Lin Liu, Di Chen, Qing Ping Dou, Tao Jiang. Polyphosphorous acid catalyzed cyclization in the synthesis of cryptolepine derivatives[J]. Chinese Chemical Letters, 2007, 18(10): 1178-1181. doi: 10.1016/j.cclet.2007.08.014

Polyphosphorous acid catalyzed cyclization in the synthesis of cryptolepine derivatives
摘要:
11-Oxo-10, 11-dihydroxy-5H-indolo[3, 2, b]quinoline 7-carboxylic acid was obtained specifically by polyphosphorous acid catalyzed cyclization with optimal reaction conditions. Biological assays showed that it potentially inhibits the proteasomal chymotrypsin-like activity in vitro and suppresses breast cancer cell growth.
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关键词:
- Cryptolepine
- / Trioligomer
- / Synthesis
- / Proteasome
English
Polyphosphorous acid catalyzed cyclization in the synthesis of cryptolepine derivatives
Abstract:
11-Oxo-10, 11-dihydroxy-5H-indolo[3, 2, b]quinoline 7-carboxylic acid was obtained specifically by polyphosphorous acid catalyzed cyclization with optimal reaction conditions. Biological assays showed that it potentially inhibits the proteasomal chymotrypsin-like activity in vitro and suppresses breast cancer cell growth.
-
Key words:
- Cryptolepine
- / Trioligomer
- / Synthesis
- / Proteasome

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