引用本文:
Davinder Kumar, Archana Kapoor, Ananda Thangadurai, Pradeep Kumar, Balasubramanian Narasimhan. Synthesis, antimicrobial evaluation and QSAR studies of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides[J]. Chinese Chemical Letters,
2011, 22(11): 1293-1296.
doi:
10.1016/j.cclet.2011.06.014
Citation: Davinder Kumar, Archana Kapoor, Ananda Thangadurai, Pradeep Kumar, Balasubramanian Narasimhan. Synthesis, antimicrobial evaluation and QSAR studies of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides[J]. Chinese Chemical Letters, 2011, 22(11): 1293-1296. doi: 10.1016/j.cclet.2011.06.014
Citation: Davinder Kumar, Archana Kapoor, Ananda Thangadurai, Pradeep Kumar, Balasubramanian Narasimhan. Synthesis, antimicrobial evaluation and QSAR studies of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides[J]. Chinese Chemical Letters, 2011, 22(11): 1293-1296. doi: 10.1016/j.cclet.2011.06.014
Synthesis, antimicrobial evaluation and QSAR studies of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides
摘要:
A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides (1-20) was synthesized and tested for in vitro antimicrobial activity. The results of antimicrobial studies indicated that the compounds having dinitro, methoxy, hydroxy and nitro substituents on phenyl ring of the aromatic acids were most active ones. The QSAR investigation indicated the importance of the topological parameter, third order molecular connectivity index (3χ) in describing the antimicrobial activity of synthesized hydrazides.
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关键词:
- Benzylidene hydrazides
- / Synthesis
- / Antimicrobial
- / mt-QSAR
- / LOO method
English
Synthesis, antimicrobial evaluation and QSAR studies of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides
Abstract:
A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides (1-20) was synthesized and tested for in vitro antimicrobial activity. The results of antimicrobial studies indicated that the compounds having dinitro, methoxy, hydroxy and nitro substituents on phenyl ring of the aromatic acids were most active ones. The QSAR investigation indicated the importance of the topological parameter, third order molecular connectivity index (3χ) in describing the antimicrobial activity of synthesized hydrazides.
-
Key words:
- Benzylidene hydrazides
- / Synthesis
- / Antimicrobial
- / mt-QSAR
- / LOO method
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