ESI/MS of N-(O, O-Diisopropyl) Phosphoryl Aromatic Amino Acids and their Stability Investigation Using HPLC/UV/ESI/MS

Hong Xia LIU Shu Sheng ZHANG Jian Chen ZHANG Xiao YANG Ling Bo QU Yu Fen ZHAO

引用本文: Hong Xia LIU,  Shu Sheng ZHANG,  Jian Chen ZHANG,  Xiao YANG,  Ling Bo QU,  Yu Fen ZHAO. ESI/MS of N-(O, O-Diisopropyl) Phosphoryl Aromatic Amino Acids and their Stability Investigation Using HPLC/UV/ESI/MS[J]. Chinese Chemical Letters, 2005, 16(5): 643-646. shu
Citation:  Hong Xia LIU,  Shu Sheng ZHANG,  Jian Chen ZHANG,  Xiao YANG,  Ling Bo QU,  Yu Fen ZHAO. ESI/MS of N-(O, O-Diisopropyl) Phosphoryl Aromatic Amino Acids and their Stability Investigation Using HPLC/UV/ESI/MS[J]. Chinese Chemical Letters, 2005, 16(5): 643-646. shu

ESI/MS of N-(O, O-Diisopropyl) Phosphoryl Aromatic Amino Acids and their Stability Investigation Using HPLC/UV/ESI/MS

  • 基金项目:

    The authors would like to thank for the supporting of Henan Outstanding Youth Grant (04120001200) and Henan Outstanding People Innovation Grant (0421002300).

摘要: The full scan ESI/MS and ESI/MS2 of N-(O, O-diisopropyl) phosphoryl aromatic amino acids (DIPPAAAs), N-(O, O-diisopropyl) phosphoryl phenylalanine, N-(O, O-diisopropyl)phosphoryl tryptophan and N-(O, O-diisopropyl) phosphoryl tyrosine, were obtained. The specific ions for them were found. Their stability in the LC mobile phase was investigated using developed HPLC/UV/ESI/MS and the results demonstrated that the DIPPAAAs were stable in the mobile phase (5 mmol/L NH4Ac-MeCN (80:20,v/v, pH7.5) within 48 h.

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  • 收稿日期:  2004-05-09
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