有机聚合物材料电致化学发光在生化分析中的应用研究进展

引用本文: 崔琳, 王鹏雨, 王成铭, 张春阳. 有机聚合物材料电致化学发光在生化分析中的应用研究进展[J]. 分析化学, 2021, 49(5): 665-675. doi: 10.19756/j.issn.0253-3820.201722 shu

Citation: CUI Lin, WANG Peng-Yu, WANG Cheng-Ming, ZHANG Chun-Yang. Advance in Applications of Organic Polymer-based Electrochemiluminescence in Biochemical Analysis[J]. Chinese Journal of Analytical Chemistry, 2021, 49(5): 665-675. doi: 10.19756/j.issn.0253-3820.201722 shu

有机聚合物材料电致化学发光在生化分析中的应用研究进展

山东师范大学化学化工与材料科学学院, 济南 250014

通讯作者: 张春阳,E-mail:cyzhang@sdnu.edu.cn

基金项目:
国家自然科学基金项目（Nos.21735003，21527811，21605096，21974080）和山东省泰山学者优势特色学科人才团队项目资助。

摘要: 电致化学发光（Electrochemiluminescence，ECL）是在电极表面产生激发态自由基粒子，然后经过电子转移反应形成激发态发光的过程。有机聚合材料是一类由一种或几种分子/分子团（结构单元或单体）以共价键结合形成具有多个重复单体/单元的材料，包括金属有机框架材料（Metal-organic frameworks，MOFs）、金属-有机凝胶（Metal-organic gels，MOGs）、共轭微孔聚合材料（Conjugated microporous polymers，CMPs）和聚合点（Polymer dots，Pdots）等。有机聚合材料与含镉量子点相比，具有低毒和良好生物相容性等优点。有机聚合材料既可作为ECL发光体，也可增强发光体的ECL信号。基于有机聚合物材料构建的ECL传感器具有选择性好、特异性高、设备简单、信号稳定、检测方便、灵敏度高、动态范围宽和低背景等优点，广泛用于环境监测、免疫分析和核糖核酸检测等领域。本文综述了有机聚合物材料ECL在生化分析中的应用研究进展，着重介绍了有机聚合物材料ECL传感器用于金属离子、生物小分子、核糖核酸和蛋白质的检测研究，对有机聚合物材料ECL传感器的发展趋势进行了展望。

关键词:

English

Advance in Applications of Organic Polymer-based Electrochemiluminescence in Biochemical Analysis

College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China

Corresponding author: ZHANG Chun-Yang, cyzhang@sdnu.edu.cn

Received Date: 03 December 2020
Revised Date: 26 February 2021
Fund Project:
Supported by the National Natural Science Foundation of China (Nos.21735003, 21527811, 21605096, 21974080).

Abstract: Electrochemiluminescence (ECL) is the process of producing species on the surface of electrodes and the subsequent formation of excited luminescence through electron transfer reaction. Organic polymeric materials are constructed by one or more molecules/molecular groups (structural units or monomers) which are covalently bonded to form multiple repeating monomer units. Organic polymers include metal-organic frameworks (MOFs), metal-organic gels (MOGs), conjugated microporous polymers (CMPs) and polymer dots (Pdots). In comparison with the cadmium-containing quantum dots, organic polymer materials have significant advantages including low toxicity and good biocompatibility, and they not only function as the ECL emitter, but also enhance the ECL signal. The organic polymer-based ECL sensors are characterized by good selectivity, high specificity, simple equipment, stable signal, easy measurement, high sensitivity, wide dynamic range, and low background, and they are widely applied to environmental monitoring, immunoassay, and nucleic acids analysis. This review summarizes the recent advance in applications of organic polymer-based ECL sensors in biochemical analysis, and focuses on the selective detection of metal ions, small biological molecules, nucleic acids, and proteins. In addition, we highlight the challenges and trends in the development of organic polymer-based ECL sensors.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

有机聚合物材料电致化学发光在生化分析中的应用研究进展

通讯作者: 张春阳,E-mail:cyzhang@sdnu.edu.cn

English

Advance in Applications of Organic Polymer-based Electrochemiluminescence in Biochemical Analysis

Corresponding author: ZHANG Chun-Yang, cyzhang@sdnu.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

有机聚合物材料电致化学发光在生化分析中的应用研究进展

通讯作者: 张春阳,E-mail:cyzhang@sdnu.edu.cn

English

Advance in Applications of Organic Polymer-based Electrochemiluminescence in Biochemical Analysis

Corresponding author: ZHANG Chun-Yang, cyzhang@sdnu.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

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