3种金属有机骨架材料用于开管毛细管电色谱手性固定相分离外消旋体

引用本文: 朱鹏静, 陶勇, 章俊辉, 字敏, 袁黎明. 3种金属有机骨架材料用于开管毛细管电色谱手性固定相分离外消旋体[J]. 色谱, 2016, 34(12): 1219-1227. doi: 10.3724/SP.J.1123.2016.06040 shu

Citation: ZHU Pengjing, TAO Yong, ZHANG Junhui, ZI Min, YUAN Liming. Three chiral metal organic frameworks used as stationary phases for the separation of racemates by open tubular capillary electrochromatography[J]. Chinese Journal of Chromatography, 2016, 34(12): 1219-1227. doi: 10.3724/SP.J.1123.2016.06040 shu

3种金属有机骨架材料用于开管毛细管电色谱手性固定相分离外消旋体

朱鹏静 ^1, ,
陶勇 ^2, ,
章俊辉 ^1, ,
字敏 ^1, ,
袁黎明 ^1,

1.
云南师范大学化学化工学院, 云南昆明 650500;
2.
上海皓锋医药科技有限公司, 上海 201210
基金项目:
国家自然科学基金项目（21275126）.

摘要: 金属有机骨架（MOFs）材料因具有丰富的拓扑结构、高比表面积、良好的稳定性、持久的孔结构以及可修饰的孔道表面等特点，在对映选择性催化和手性分离方面备受关注。该文通过水热法合成了3种具有手性的MOFs晶体，分别为Co₂（D-cam）₂（TMDPy）（简称为MOF 1）、[Cd（D-cam）（tmdpy）]·2H₂O（简称为MOF 2）和[Co_0.5Zn_0.5（L-Tyr）]_n（L-tyrCo/Zn）（简称为MOF 3），并把它们用作固定相分别制成MOFs手性柱进行开管毛细管电色谱（OT-CEC）研究。在磷酸二氢钠-乙腈的流动相体系下，考察了3根MOFs手性柱对手性化合物的拆分性能。实验结果表明，这3种MOFs手性毛细管柱对部分外消旋体具有较好的拆分效果。目前将手性MOFs作为毛细管电色谱手性分离的研究正处在起步阶段并且具有良好的应用前景。

关键词:

English

Three chiral metal organic frameworks used as stationary phases for the separation of racemates by open tubular capillary electrochromatography

1.
School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China;
2.
Shanghai Hao Feng Pharmaceutical Technology Company Limited, Shanghai 201210, China
Received Date: 24 June 2016
Fund Project:
National Natural Science Foundation of China (No. 21275126).

Abstract: Metal organic frameworks (MOFs) have attracted a tremendous attention in enantioselective catalysis and separation due to their unusual properties such as rich topologies, high surface area, good stability, permanent micropocity, availability of outer-surface modification and so on. In this study, three chiral MOFs, Co₂(D-cam)₂(TMDPy) (abbreviated as MOF 1),[Cd(D-cam)(tmdpy)]·2H₂O (abbreviated as MOF 2) and[Co_0.5Zn_0.5(L-Tyr)]_n(L-tyrCo/Zn) (abbreviated as MOF 3) were synthesized and respectively used as chiral stationary phases in open tubular capillary electrochromatography (OT-CEC). The three MOFs were characterized by powder X-ray diffraction (XRD) and scanning electron microscope (SEM). The three MOFs coated columns were developed using a simple procedure via MOFs post-coated on the sodium silicate layer. The experimental results showed that the three MOFs based chiral columns had better recognition ability toward some racemates. The baseline separation of furoin was achieved on the MOF 1 coated column with high resolution of more than 2.10. The influences of pH, organic modifier content and buffer concentration on the separation were investigated. The results demonstrated that chiral MOFs were promising for enantioseparation in CEC.

Key words:

1. [1] Zhai R, Jiao F L, Lin H J, et al. Chinese Journal of Chromatography, 2014, 32(2):107 翟睿, 焦丰龙, 林虹君, 等. 色谱, 2014, 32(2):107
2. [2] Xie S M, Liu H, Yang J R, et al. Chinese Journal of Chromatography, 2016, 34(1):113 谢生明, 刘虹, 杨江蓉, 等. 色谱, 2016, 34(1):113
3. [3] Chen B L, Liang C D, Yang J, et al. Angew Chem Int Ed, 2006, 45(9):1390
4. [4] Jhung S H, Lee J H, Yoon J W. Adv Mater, 2007, 19(1):121
5. [5] Gu Z Y, Yan X P. Angew Chem Int Ed, 2010, 49(8):1477
6. [6] Xie S M, Zhang Z J, Wang Z Y, et al. J Am Chem Soc, 2011, 133(31):11892
7. [7] Alaerts L, Kirschhock C E A, Maes M, et al. Angew Chem Int Ed, 2007, 46(23):4293
8. [8] Alaerts L, Maes M, Giebeler L, et al. J Am Chem Soc, 2008, 130(43):14170
9. [9] Yang C X, Yan X P. Anal Chem, 2011, 83(18):7144
10. [10] Tanaka K, Muraoka T, Hirayama D, et al. Chem Commun, 2012, 48(68):8577
11. [11] Zhang M, Pu Z J, Chen X L, et al. Chem Comm, 2013, 49(45):5201
12. [12] Li L M, Wang H F, Yan X P. Electrophoresis, 2012, 33:2896
13. [13] Huang H Y, Lin C L, Cheng Y J, et al. Anal Chim Acta, 2013, 779:96
14. [14] Li L M, Yang F, Wang H F, et al. J Chromatogr A, 2013, 1316:97
15. [15] Fei Z X, Zhang M, Zhang J H, et al. Anal Chim Acta, 2014, 830:49
16. [16] Xuan W, Zhu C, Liu Y, et al. Chem Soc Rev, 2012, 41(5):1677
17. [17] Zhang J, Chew E, Chen S M, et al. Inorg Chem, 2008, 47:3495
18. [18] Zhang J, Xian H B. Angew Chem Int Ed, 2007, 46:6115
19. [19] Zhang M, Xue X D, Zhang J H, et al. Anal Methods, 2014, 6(24):341
20. [20] Fei Z X, Zhang M, Xie S M, et al. Electrophoresis, 2014, 35:3541
21. [21] Zhou B, Silva Nuno J O, Fa N S, et al. Eur J Inorg Chem, 2012, 32:5259
22. [22] Qi X Y, Li X J, Bai Y, et al. Chinese Journal of Chromatography, 2016, 34(1):10 祁晓月, 李先江, 白玉, 等. 色谱, 2016, 34(1):10

扫一扫看文章

计量

PDF下载量: 5
文章访问数: 1144
HTML全文浏览量: 177

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

3种金属有机骨架材料用于开管毛细管电色谱手性固定相分离外消旋体

English

Three chiral metal organic frameworks used as stationary phases for the separation of racemates by open tubular capillary electrochromatography

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

3种金属有机骨架材料用于开管毛细管电色谱手性固定相分离外消旋体

English

Three chiral metal organic frameworks used as stationary phases for the separation of racemates by open tubular capillary electrochromatography

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs