Design, synthesis and biological estimation of 1-(benzoxazole-2-y1)piperazine and 4-(benzoxazole-2-yl)piperidine derivatives as potential α₁-AR antagonists

• Jia Bin Li ^a, ,
• Lin Xia ^b, ,
• Bin Wu ^d, ,
• Tao Wang ^c, ,
• Zhen Zhou Jiang ^c,

• a Department of Inorganic Chemistry, China Pharmaceutical University, Nanjing 210009, China;

• b Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China;

• c National Drug Screening Center, China Pharmaceutical University, Nanjing 210009, China;

• d School of Pharmacy, Nanjing Medical University, Nanjing 210029, China

• Received Date: 15 April 2008
  
• Fund Project:

  This work was supported by the National High-Tech Research and Development Plan (No. 2002AA2Z3118). We also thank Prof. Xiaowen Xue for general help in manuscript preparation.