引用本文:
朱益忠, 张喜全, 刘飞, 顾红梅, 朱海亮. 邻氯苯甲腈的新合成法[J]. 应用化学,
2013, 30(8): 971-973.
doi:
10.3724/SP.J.1095.2013.20530
Citation: ZHU Yizhong, ZHANG Xiquan, LIU Fei, GU Hongmei, ZHU Hailiang. A New Synthetic Route Toward o-Chlorobenzonitrile[J]. Chinese Journal of Applied Chemistry, 2013, 30(8): 971-973. doi: 10.3724/SP.J.1095.2013.20530
Citation: ZHU Yizhong, ZHANG Xiquan, LIU Fei, GU Hongmei, ZHU Hailiang. A New Synthetic Route Toward o-Chlorobenzonitrile[J]. Chinese Journal of Applied Chemistry, 2013, 30(8): 971-973. doi: 10.3724/SP.J.1095.2013.20530
邻氯苯甲腈的新合成法
摘要:
以邻氯溴苯为起始原料,选用K4[Fe(CN)6]为氰基化试剂,Pd/C催化反应制得邻氯苯甲腈。考察了温度、碱、催化剂的用量和原料比等对反应的影响,确定了较佳反应条件。邻氯溴苯转化率达98.5%,产物邻氯苯甲腈得率95.1%。
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关键词:
- 邻氯溴苯
- / K4[Fe(CN)6]
- / 氰基化反应
English
A New Synthetic Route Toward o-Chlorobenzonitrile
Abstract:
o-Chlorobenzonitrile was prepared from the cyanization reaction of o-chlorobromobenzene using potassium ferrocyanide as cyanating agent and Pd/C as a catalyst. The reaction conditions were optimized through investigating the reaction temperature,base,the amount of catalyst,the ratio of reactants. The conversion of the o-chlorobromobenzene to target product could reach 98.5% and the yield of o-chlorobenzonitrile was 95.1%.
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Key words:
- o-chlorobromobenzene
- / potassium ferrocyanide
- / cyanization reaction
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