引用本文:
Harish Rajak, Chinmay K. Behera, Rajesh S. Pawar, Pradeep K. Singour, Murli Dhar Kharya. A novel series of 2,5-disubstituted 1,3,4-thiadiazoles as potential anticonvulsant agent[J]. Chinese Chemical Letters,
2010, 21(10): 1149-1152.
doi:
10.1016/j.cclet.2010.04.012
Citation: Harish Rajak, Chinmay K. Behera, Rajesh S. Pawar, Pradeep K. Singour, Murli Dhar Kharya. A novel series of 2,5-disubstituted 1,3,4-thiadiazoles as potential anticonvulsant agent[J]. Chinese Chemical Letters, 2010, 21(10): 1149-1152. doi: 10.1016/j.cclet.2010.04.012
Citation: Harish Rajak, Chinmay K. Behera, Rajesh S. Pawar, Pradeep K. Singour, Murli Dhar Kharya. A novel series of 2,5-disubstituted 1,3,4-thiadiazoles as potential anticonvulsant agent[J]. Chinese Chemical Letters, 2010, 21(10): 1149-1152. doi: 10.1016/j.cclet.2010.04.012
A novel series of 2,5-disubstituted 1,3,4-thiadiazoles as potential anticonvulsant agent
摘要:
In pursuit for better antiepileptic drug and the importance of semicarbazones and 2, 5-disubstituted 1, 3, 4-thiadiazoles as anticonvulsant pharmacophore, a series of novel N-({5-[(6-methyl-1-benzofuran-3-yl) methyl]-1, 3, 4-thiadiazol-2-yl}carba-mothioyl)-2/3/4-substitutedbenzamide were designed, synthesized and evaluated for their anticonvulsant activity. The findings of the present studies confirmed that the pharmacophore model with four binding sites is crucial for anticonvuisant activity. Structure-activity relationships among synthesized compounds were also established.
English
A novel series of 2,5-disubstituted 1,3,4-thiadiazoles as potential anticonvulsant agent
Abstract:
In pursuit for better antiepileptic drug and the importance of semicarbazones and 2, 5-disubstituted 1, 3, 4-thiadiazoles as anticonvulsant pharmacophore, a series of novel N-({5-[(6-methyl-1-benzofuran-3-yl) methyl]-1, 3, 4-thiadiazol-2-yl}carba-mothioyl)-2/3/4-substitutedbenzamide were designed, synthesized and evaluated for their anticonvulsant activity. The findings of the present studies confirmed that the pharmacophore model with four binding sites is crucial for anticonvuisant activity. Structure-activity relationships among synthesized compounds were also established.
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Key words:
- 1,3,4-Thiadiazoles
- / Semicarbazones
- / Anticonvulsant activity
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