引用本文:
Jin Yi Xu, Qian Ran, Wei Yi Hua, Xiao Ming Wu, Qiu Juan Wang, Jing Zhang. Design and synthesis of 2-alkylbenzimidazole derivatives as novel non-peptide angiotensin Ⅱ AT1 receptor antagonists[J]. Chinese Chemical Letters,
2007, 18(3): 251-254.
doi:
10.1016/j.cclet.2006.12.029
Citation: Jin Yi Xu, Qian Ran, Wei Yi Hua, Xiao Ming Wu, Qiu Juan Wang, Jing Zhang. Design and synthesis of 2-alkylbenzimidazole derivatives as novel non-peptide angiotensin Ⅱ AT1 receptor antagonists[J]. Chinese Chemical Letters, 2007, 18(3): 251-254. doi: 10.1016/j.cclet.2006.12.029
Citation: Jin Yi Xu, Qian Ran, Wei Yi Hua, Xiao Ming Wu, Qiu Juan Wang, Jing Zhang. Design and synthesis of 2-alkylbenzimidazole derivatives as novel non-peptide angiotensin Ⅱ AT1 receptor antagonists[J]. Chinese Chemical Letters, 2007, 18(3): 251-254. doi: 10.1016/j.cclet.2006.12.029
Design and synthesis of 2-alkylbenzimidazole derivatives as novel non-peptide angiotensin Ⅱ AT1 receptor antagonists
摘要:
A series of 2-alkylbenzimidazole derivatives 9a-n have been designed and synthesized as a novel class of non-peptide angiotensin Ⅱ AT1 receptor antagonists. The synthesized compounds were evaluated for their antagonism of angiotensin Ⅱ, induced contraction in the rabbit thoracic aortic ring and the results showed that compounds 9a, 9g and 9j exhibited potent antagonistic activity of AT1 receptor.
English
Design and synthesis of 2-alkylbenzimidazole derivatives as novel non-peptide angiotensin Ⅱ AT1 receptor antagonists
Abstract:
A series of 2-alkylbenzimidazole derivatives 9a-n have been designed and synthesized as a novel class of non-peptide angiotensin Ⅱ AT1 receptor antagonists. The synthesized compounds were evaluated for their antagonism of angiotensin Ⅱ, induced contraction in the rabbit thoracic aortic ring and the results showed that compounds 9a, 9g and 9j exhibited potent antagonistic activity of AT1 receptor.
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Key words:
- 2-Alkylbenzimidazole
- / AT1receptor antagonists
- / Synthesis
- / Hypertension
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