Citation:
ZHANG Jing-Yi, ZHONG Han-Yu, SHI Guo-Bing. Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae[J]. Chinese Journal of Structural Chemistry,
2014, 33(6): 876-880.
Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae
摘要:
Many small-molecule compounds have been evaluated with potential antiproliferative activities. Ethyl 1-(phenylcarbamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, one novel cyclopropylamide analogue of combretastatin-A4 (CA-4), has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P21/c, with a=15.0263(3), b=7.6574(2), c=19.4117(4)Å, β=111.9010(10)°, V=2072.36(8)Å3, Z=4, C22H24NO6, Mr=398.42, Dc=1.277 Mg/cm3, F(000)=844, λ(MoKα)=1.54178Å, μ=0.770 mm-1, R=0.0546 and wR=0.1889 for 3319 observed reflections (I>2σ(I)). Meanwhile, the compound revealed potential antiproliferative activities in several cancer cells in vitro.
English
Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae
Abstract:
Many small-molecule compounds have been evaluated with potential antiproliferative activities. Ethyl 1-(phenylcarbamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, one novel cyclopropylamide analogue of combretastatin-A4 (CA-4), has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P21/c, with a=15.0263(3), b=7.6574(2), c=19.4117(4)Å, β=111.9010(10)°, V=2072.36(8)Å3, Z=4, C22H24NO6, Mr=398.42, Dc=1.277 Mg/cm3, F(000)=844, λ(MoKα)=1.54178Å, μ=0.770 mm-1, R=0.0546 and wR=0.1889 for 3319 observed reflections (I>2σ(I)). Meanwhile, the compound revealed potential antiproliferative activities in several cancer cells in vitro.
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Key words:
- 3,4,5-trimethoxyphenyl
- / synthesis
- / crystal structure
- / antiproliferative activities
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