Citation:
DUAN Li-Ping, QIN Zhi-Qiang, LI Guang-Ping, LI Shi-Zhu, LI Qiang, XU Dong-Fang. Synthesis, Crystal Structure and Biological Evaluation of 4-Chloro-2-(morpholine-4-carbonyl)phenyl-4'-methoxybenzoate as Molluscicidal Agent[J]. Chinese Journal of Structural Chemistry,
2014, 33(6): 841-845.
Synthesis, Crystal Structure and Biological Evaluation of 4-Chloro-2-(morpholine-4-carbonyl)phenyl-4'-methoxybenzoate as Molluscicidal Agent
摘要:
The title compound 4-chloro-2-(morpholine-4-carbonyl)phenyl-4'-methoxybenzoate (C19H18ClNO5, Mr=375.79), a 5-chlorosalicylic acid derivative incorporating morpholine moiety, was conveniently synthesized through two steps and crystallized in the monoclinic space group P21/c with a=7.8501(10), b=9.3149(12), c=25.133(3)Å, V=1836.2(4)Å3, Z=4, Dc=1.359 Mg/m3, λ=0.71073Å, μ(MoKα)=0.237 mm-1, F(000)=784, R=0.0447 and wR=0.1227 for 3982 independent reflections with I>2σ(I). The dihedral angles formed between 4-methoxybenzene and 5-chlorobenzene rings, the 5-chlorobenzene and morpholine, and 4-methoxybenzene and morpholine rings are 82.55(3), 72.56(5) and 47.68(0)° by X-ray analysis, respectively. Bioassay shows that the title compound has a good molluscidal effect.
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关键词:
- salicylic acid
- / crystal structure
- / molluscidal
English
Synthesis, Crystal Structure and Biological Evaluation of 4-Chloro-2-(morpholine-4-carbonyl)phenyl-4'-methoxybenzoate as Molluscicidal Agent
Abstract:
The title compound 4-chloro-2-(morpholine-4-carbonyl)phenyl-4'-methoxybenzoate (C19H18ClNO5, Mr=375.79), a 5-chlorosalicylic acid derivative incorporating morpholine moiety, was conveniently synthesized through two steps and crystallized in the monoclinic space group P21/c with a=7.8501(10), b=9.3149(12), c=25.133(3)Å, V=1836.2(4)Å3, Z=4, Dc=1.359 Mg/m3, λ=0.71073Å, μ(MoKα)=0.237 mm-1, F(000)=784, R=0.0447 and wR=0.1227 for 3982 independent reflections with I>2σ(I). The dihedral angles formed between 4-methoxybenzene and 5-chlorobenzene rings, the 5-chlorobenzene and morpholine, and 4-methoxybenzene and morpholine rings are 82.55(3), 72.56(5) and 47.68(0)° by X-ray analysis, respectively. Bioassay shows that the title compound has a good molluscidal effect.
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Key words:
- salicylic acid
- / crystal structure
- / molluscidal
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