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联咪唑镍、镉配合物的合成、晶体结构及其与DNA相互作用

杨莉宁 ,  黑嘉慧 ,  成昭 ,  李立 ,  余丽丽

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引用本文: 杨莉宁, 黑嘉慧, 成昭, 李立, 余丽丽. 联咪唑镍、镉配合物的合成、晶体结构及其与DNA相互作用[J]. 应用化学, 2016, 33(6): 710-718. doi: 10.11944/j.issn.1000-0518.2016.06.150350 shu
Citation:  YANG Lining, HEI Jiahui, CHENG Zhao, Li li, YU Lili. Synthesis, Crystal Structures and DNA Interaction of Nickel and Cadmium Complexes Involving Biimidazole[J]. Chinese Journal of Applied Chemistry, 2016, 33(6): 710-718. doi: 10.11944/j.issn.1000-0518.2016.06.150350 shu

联咪唑镍、镉配合物的合成、晶体结构及其与DNA相互作用

  • 1.

    a 西安医学院药学院 西安 710021;

  • 2.

    b 陕西航天职工大学 西安 710100

    • 通讯作者: 杨莉宁,副教授;Tel/Fax:029-86177549;E-mail:zyfyln828@163.com;研究方向:生物无机化学
  • 基金项目:

    国家自然科学基金（81302706）资助项目 

    国家级大学生创新创业训练计划项目（201411840023）资助 

摘要: 分别通过水热法和室温挥发法合成了2,2'-联咪唑（H2biim）镍、镉配合物（[Ni（H2biim）3]（phth）（phth，邻苯二甲酸根）（1）、[Cd（H3biim）2Cl4]（2）），并通过X射线单晶衍射、元素分析和红外等技术手段对它们进行了表征。单晶X衍射结果表明，配合物1的配离子中心镍离子周围的配体以3个中性联咪唑分子形式分别进行二齿螯合配位，构成六配位的畸变八面体构型，邻苯二甲酸根离子在外界与配体形成丰富的氢键；而在配合物2中，两个联咪唑配体却以含有氢质子的阳离子H3biim+形式与中心镉离子单齿配位，镉离子同时结合4个氯原子形成六配位配位环境。通过紫外光谱、荧光光谱和黏度法测试结果表明配合物1和2分别与小牛胸腺DNA（ct-DNA）以经典插入和部分插入模式进行相互作用。

English

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  • 收稿日期:  2015-09-28
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