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可见光诱导烯烃环化合成二氟烷基化异喹啉二酮

李捷 ,  刘益林 ,  邓佑林 ,  王文新 ,  王硕文 ,  李增增 ,  唐石

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引用本文: 李捷, 刘益林, 邓佑林, 王文新, 王硕文, 李增增, 唐石. 可见光诱导烯烃环化合成二氟烷基化异喹啉二酮[J]. 应用化学, 2016, 33(6): 677-684. doi: 10.11944/j.issn.1000-0518.2016.06.150316 shu
Citation:  LI Jie, LIU Yilin, DENG Youlin, WANG Wenxin, WANG Shuowen, LI Zengzeng, TANG Shi. Visible-Light-Induced Cyclization of Alkenes to Form Difluoroacetating Isoquinolinedione[J]. Chinese Journal of Applied Chemistry, 2016, 33(6): 677-684. doi: 10.11944/j.issn.1000-0518.2016.06.150316 shu

可见光诱导烯烃环化合成二氟烷基化异喹啉二酮

  • 1.

    a 吉首大学化学化工学院 湖南 吉首 416000;

  • 2.

    b 怀化学院, 功能无机及高分子材料怀化市重点实验室 湖南 怀化 418008

    • 通讯作者: 唐石,副教授;Tel/Fax:0743-8563911;E-mail:stang@jsu.edu.cn;研究方向:有机催化与合成;刘益林,讲师;Tel/Fax:0745-2851014;E-mail:liuyilinhn@126.com;研究方向:有机催化与合成; 唐石,副教授;Tel/Fax:0743-8563911;E-mail:stang@jsu.edu.cn;研究方向:有机催化与合成;刘益林,讲师;Tel/Fax:0745-2851014;E-mail:liuyilinhn@126.com;研究方向:有机催化与合成
  • 基金项目:

    国家自然基金资助项目（21462017） 

摘要: 发展了一种可见光诱导的活泼烯烃串联自由基环化合成含氟异喹啉二酮的反应。在可见光诱导下，多种N-烷基-N-甲基丙烯酰基苯甲酰胺与二氟溴乙酸乙酯发生自由基串联环化反应，以66%～75%的产率合成了一系列具有潜在生理活性的二氟烷基化异喹啉二酮。此研究为合成具有潜在药用价值的氟取代异喹啉二酮提供了一条高效、条件温和的途径。

English

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  • 收稿日期:  2015-08-31
  • 网络出版日期:  2015-12-23
通讯作者: 陈斌, bchen63@163.com
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