引用本文:
刘湘, 李纪国, 张正. 奎宁与钴(Ⅱ)手性络合物用于前手性酮的不对称催化还原[J]. 应用化学,
1997, 14(4): 88-90.
Citation: Liu Xiang, Li Jiguo, Zhang Zheng. Catalytic Asymmetric Reduction of Prochiral Ketones in the Presence of Chiral Quinine-Co(Ⅱ) Complex[J]. Chinese Journal of Applied Chemistry, 1997, 14(4): 88-90.
Citation: Liu Xiang, Li Jiguo, Zhang Zheng. Catalytic Asymmetric Reduction of Prochiral Ketones in the Presence of Chiral Quinine-Co(Ⅱ) Complex[J]. Chinese Journal of Applied Chemistry, 1997, 14(4): 88-90.
奎宁与钴(Ⅱ)手性络合物用于前手性酮的不对称催化还原
English
Catalytic Asymmetric Reduction of Prochiral Ketones in the Presence of Chiral Quinine-Co(Ⅱ) Complex
Abstract:
A chiral complex, in situ prepared from (-)-quinine and CoCl2 was used as catalyst for asymmetric reduction of aromatic prochiral ketones:p-R2C6H4COR1(R1, R2 shown in Tab.1) and some products with moderate enantiomeric excesses were obtained. Effects of KBH4 and LiAlH4 as reductant and reaction temperature and time on the reaction were investigated.
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Key words:
- chiral complex
- / asymmetric reduction
- / aromatic prochiral ketone
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