引用本文:
张万轩, 雷策南, 黄锦霞, 陈家威. 制备1-氰基-2,3,5-三-O-苯甲酰基-β-D-呋喃核糖的简便方法[J]. 应用化学,
1997, 14(3): 115-116.
Citation: Zhang Wanxuan, Lei Cenan, Huang Jinxia, Chen Jiawei. Synthesis of 1-Cyano-2,3,5-tri-O-benzoyl-β-D-ribofuranose[J]. Chinese Journal of Applied Chemistry, 1997, 14(3): 115-116.
Citation: Zhang Wanxuan, Lei Cenan, Huang Jinxia, Chen Jiawei. Synthesis of 1-Cyano-2,3,5-tri-O-benzoyl-β-D-ribofuranose[J]. Chinese Journal of Applied Chemistry, 1997, 14(3): 115-116.
制备1-氰基-2,3,5-三-O-苯甲酰基-β-D-呋喃核糖的简便方法
摘要:
1-氰基-2,3,5-三-O-苯甲酰基-U-D-呋喃核糖(1)是制备核苷类物质的重要前体,近年来也用作一些核苷类药物的合成原料.
-
关键词:
- 鸟苷
- / 制备
- / 氰基三苯甲酰基-U-D-呋喃核糖
- / 三甲基氯硅烷
English
Synthesis of 1-Cyano-2,3,5-tri-O-benzoyl-β-D-ribofuranose
Abstract:
Reacting guanosine with benzoyl chloride gave a mixture containing 2',3',5'-tribenzoyl guanosine. After distillation in vacuum the residual solid was acetylated directly and 1-O-acetyl-2,3,5-tri-O-benzoyl-U-D-ribofuranose (2) was obtained. Being reacted with Me3SiCN, (2) led to the title compound(1). The method reported here is more convenient and cheaper with a considerably higher yield.
-
Key words:
- guanosine
- / cyano-tri-O-benzoyl-U-D-ribofuranose
- / synthesis
- / chloro-trimethylsilane
-
-
扫一扫看文章
计量
- PDF下载量: 0
- 文章访问数: 361
- HTML全文浏览量: 12
下载:
