引用本文:
王茹林, 杨郁, 双少敏, 潘景浩. β-环糊精衍生物对黄酮类药物的增溶作用[J]. 应用化学,
2002, 19(7): 702-704.
Citation: WANG Ru-Lin, YANG Yu, SHUANG Shao-Min, PAN Jing-Hao. Enhanced Solubility of Flavonoids by Inclusion with β-Cyclodextrin and Its Derivatives[J]. Chinese Journal of Applied Chemistry, 2002, 19(7): 702-704.
Citation: WANG Ru-Lin, YANG Yu, SHUANG Shao-Min, PAN Jing-Hao. Enhanced Solubility of Flavonoids by Inclusion with β-Cyclodextrin and Its Derivatives[J]. Chinese Journal of Applied Chemistry, 2002, 19(7): 702-704.
β-环糊精衍生物对黄酮类药物的增溶作用
English
Enhanced Solubility of Flavonoids by Inclusion with β-Cyclodextrin and Its Derivatives
Abstract:
The inclusion interactions between flavonoids and U-cyclodextrin(U-CD) and its derivatives have been studied by a phase solubility method. The phase solubility graphs showed that the 1:1 inclusion compounds were formed beween U-CD and rutin, qucertin and morin respectively. The compounds appeared to be a type of AL inclusion. U-CD derivatives have stronger binding capacity than U-CD. The enhanced solubility of compounds decreased in the order methyl-U-CD > hydroxypropyl-U-CD > U-CD. The highest solubility was obtained in methyl-U-CD inclusion complex with qucertin in level of 50 times than that in water.
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Key words:
- phase solubility
- / U-cyclodextrin and its derivatives
- / flavonoids
- / solubility
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