引用本文:
孙纲春, 常俊标, 陈荣峰, 谢晶曦, 程桂芳, 王流芳, 何娟, 王利敏. E,E-1-(3'-吲哚基)-5-取代苯基-1,4-戊二烯-3-酮化合物的合成及抗炎活性[J]. 应用化学,
2002, 19(7): 621-624.
Citation: SUN Gang-Chun, CHANG Jun-Biao, CHEN Rong-Feng, XIE Jing-Xi, CHENG Gui-Fang, WANG Liu-Fang, HE Juan, WANG Li-Min. Synthesis and Anti-inflammatory Activity of E,E-1-(3'-Indolyl)-5-(substituted phenyl)-1,4-pentadien-3-one Derivatives[J]. Chinese Journal of Applied Chemistry, 2002, 19(7): 621-624.
Citation: SUN Gang-Chun, CHANG Jun-Biao, CHEN Rong-Feng, XIE Jing-Xi, CHENG Gui-Fang, WANG Liu-Fang, HE Juan, WANG Li-Min. Synthesis and Anti-inflammatory Activity of E,E-1-(3'-Indolyl)-5-(substituted phenyl)-1,4-pentadien-3-one Derivatives[J]. Chinese Journal of Applied Chemistry, 2002, 19(7): 621-624.
E,E-1-(3'-吲哚基)-5-取代苯基-1,4-戊二烯-3-酮化合物的合成及抗炎活性
English
Synthesis and Anti-inflammatory Activity of E,E-1-(3'-Indolyl)-5-(substituted phenyl)-1,4-pentadien-3-one Derivatives
Abstract:
Nine E,E-1-(3'-indolyl)-5-(substituted phenyl)-1,4-pentadien-3-one derivatives were synthesized and characterized by MS, 1H NMR and UV. Five of these compounds(1,3,4,6,7) showed a certain anti-inflammatory activity on mouse ear edema induced by croton oil with the inhibitions being 21.1%, 25.3%, 18.4%, 22.3% and 28.9% respectively (P<0.05 or P<0.01 vs control), at the hypodermic injection dose of 50 mg/kg.
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Key words:
- indole
- / pentadienone derivative
- / synthesis
- / anti-inflammatory activity
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