引用本文:
岳可芬, 周春生, 顾焕, 史真. 对甲基苯甲醛的Grignard试剂合成法[J]. 应用化学,
2002, 19(9): 905-907.
Citation: YUE Ke-Fen, ZHOU Chun-Sheng, GU Huan, SHI Zhen. Synthesis of p-Methylbenzaldehyde via Grignard Reagent[J]. Chinese Journal of Applied Chemistry, 2002, 19(9): 905-907.
Citation: YUE Ke-Fen, ZHOU Chun-Sheng, GU Huan, SHI Zhen. Synthesis of p-Methylbenzaldehyde via Grignard Reagent[J]. Chinese Journal of Applied Chemistry, 2002, 19(9): 905-907.
对甲基苯甲醛的Grignard试剂合成法
摘要:
醛类化合物尤其在香料工业中使用相当广泛。但由于其容易氧化和聚合,合成难度大,产率低[1]。对甲基苯甲醛是允许使用的食用香料之一,主要用于果仁香精,它还是合成纤维、医药、染料、增白剂的中间体,市场需求量大[2]。
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关键词:
- 对甲基苯甲醛
- / 合成
- / 二甲基苯并咪唑盐
- / Grignard试剂溴化对甲苯基镁
English
Synthesis of p-Methylbenzaldehyde via Grignard Reagent
Abstract:
p-Methylbenzaldehyde was prepared in yield of 75% by addition hydrolysis reactions of Grignard agent p-CH3C6H4MgBr with 1,3-dimethylbenzimidazolium iodide. It is a biomimetic synthetic method. The reaction was carried out under mild and convenient condition. The addition reaction and hydrolysis were of "one-pot" reaction, without necessity of isolating benzimidazolidine. The hydrolysis reaction was carried out in 5% HCl solution at 30~40℃. The addition-hydrolysis reaction mechanism has been discussed briefly.
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