引用本文:
赵瑾, 宋金勇, 王超杰, 刘蕾, 孙心齐. 3,4,5-三甲氧基苯甲酰茄呢基胺的合成[J]. 应用化学,
2003, 20(1): 95-97.
Citation: ZHAO Jin, SONG Jin-Yong, WANG Chao-Jie, LIU Lei, SUN Xin-Qi. Synthesis of 3,4,5-Trimethoxybenzoylsolanesylamide[J]. Chinese Journal of Applied Chemistry, 2003, 20(1): 95-97.
Citation: ZHAO Jin, SONG Jin-Yong, WANG Chao-Jie, LIU Lei, SUN Xin-Qi. Synthesis of 3,4,5-Trimethoxybenzoylsolanesylamide[J]. Chinese Journal of Applied Chemistry, 2003, 20(1): 95-97.
3,4,5-三甲氧基苯甲酰茄呢基胺的合成
摘要:
茄呢醇(4)(九聚异戊二烯醇,solanesol)是从烟叶中提取的一种全E式多聚异戊二烯醇,主要用于合成治疗心血管病及抗衰老药物辅酶Q10。近年国内外以茄呢醇为原料的新药研制比较活跃,已发现茄呢基胺类衍生物具有抗癌、保肝等多种生理活性[1],茄呢基胺的盐酸盐对哺乳动物有抗病毒活性[2]。
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关键词:
- 茄呢醇
- / 茄呢基胺
- / 三甲氧基苯甲酰茄呢基胺
- / 合成
English
Synthesis of 3,4,5-Trimethoxybenzoylsolanesylamide
Abstract:
3,4,5-Trimethoxybenzoyloxysolanesylamide(8) was first synthesized from solanesol in four steps. Thus, solanesyl bromide(5) prepared by the reaction of solanesol(4) and PBr3 was reacted with potassium phthalimide to give N-solanesylphthalimide(6), which was refluxed with N2H4·H2O in 95% EtOH to give solanesylamine(7). Compound 7 was then reacted with 3,4,5-trimethoxybenzoyloxyl chloride to give the title compound. Its structure has been confirmed by IR, 1H NMR, MS and elemental analysis.
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Key words:
- trimethoxybenzoylsolanesylamide
- / synthesis
- / solanesol
- / solanesylamine
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