引用本文:
卢振伟, 陈东, 刘颖, 聂毓秀, 陈杭亭, 李伟国, 倪嘉缵. 混合稀土对大鼠肝脏中7种酶的小剂量刺激作用[J]. 应用化学,
2003, 20(1): 6-9.
Citation: LU Zhen-Wei, CHEN Dong, LIU Ying, NIE Yu-Xiu, CHEN Hang-Ting, LI Wei-Guo, NI Jia-Zuan. The Hormesis Effect of Rare Earth Elements on Several Enzymes in Rats Liver[J]. Chinese Journal of Applied Chemistry, 2003, 20(1): 6-9.
Citation: LU Zhen-Wei, CHEN Dong, LIU Ying, NIE Yu-Xiu, CHEN Hang-Ting, LI Wei-Guo, NI Jia-Zuan. The Hormesis Effect of Rare Earth Elements on Several Enzymes in Rats Liver[J]. Chinese Journal of Applied Chemistry, 2003, 20(1): 6-9.
混合稀土对大鼠肝脏中7种酶的小剂量刺激作用
摘要:
研究了常乐(用于肥料添加剂的一种混合稀土硝酸盐)对Wistar大鼠肝脏中7种常见酶(ALT,ICD,AST,LAP,ALP,γ-GT,CHE)活性的变化,并用电感耦合等离子体质谱(ICP-MS)测定了稀土在肝脏中的累积情况。结果表明,稀土对多种酶表现出低剂量激活、高剂量抑制的小剂量刺激作用(Hormesis),但产生刺激作用的剂量随酶的种类不同而不同,并表现出明显的性别差异。
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关键词:
- 肝脏
- / 酶
- / 稀土
- / Hormesis作用
English
The Hormesis Effect of Rare Earth Elements on Several Enzymes in Rats Liver
Abstract:
The effects of rare earth elements(RE) on the activities of seven enzyme (ALT, ICD, AST, LAP, ALP, γ-GT, CHE) in rat liver have been investigated by analysing the accumulated amount of RE in the rat liver by ICP-MS. The results indicate the occurrence of Hormesis effect on most enzymes studied and the dependence of Hormesis dose-response range on the type and character of the enzymes. No significant relationship was observed between dosage and the accumulation of RE in the rat liver.
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Key words:
- liver
- / enzyme
- / rare earth
- / Hormesis effect
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