引用本文:
江银枝, 胡惟孝. 2-乙酰吡啶吖嗪及其与Co2+、Ni2+、Fe3+、Zn2+配合物的合成和生物活性[J]. 应用化学,
2003, 20(6): 582-585.
Citation: JIANG Yin-Zhi, HU Wei-Xiao. Synthesis and Bio-activity of Methyl-2-pyridinyl ketazine and Its Complexes with Co2+, Ni2+, Fe3+ and Zn2+[J]. Chinese Journal of Applied Chemistry, 2003, 20(6): 582-585.
Citation: JIANG Yin-Zhi, HU Wei-Xiao. Synthesis and Bio-activity of Methyl-2-pyridinyl ketazine and Its Complexes with Co2+, Ni2+, Fe3+ and Zn2+[J]. Chinese Journal of Applied Chemistry, 2003, 20(6): 582-585.
2-乙酰吡啶吖嗪及其与Co2+、Ni2+、Fe3+、Zn2+配合物的合成和生物活性
摘要:
合成了2-乙酰吡啶吖嗪和它与Co2+、Ni2+、Fe3+、Zn2+形成的配合物:[Co3Cl6L2]·4H2O,[Ni2(NO3)4L3]·9H2O,[Fe3Cl9L2]·CH3CH(OH)CH3,[Zn3Cl6L2]·7H2O。用元素分析、红外光谱、紫外光谱、摩尔电导率测定等技术对所得配合物进行了表征。用NBT法研究了配合物对超氧阴离子自由基的抑制作用;采用四氮唑盐(MTT法)还原法对P388小鼠白血病进行了体外筛选实验;用磺酰罗丹明B(SRB)蛋白染色法对A-549人肺癌进行了体外筛选实验。结果表明,配体和配合物都有一定的生物活性,Co配合物和Ni配合物活性优于配体,而Fe配合物和Zn配合物活性差,甚至不及配体。配合物的生物活性可能与中心离子的最外层d轨道的电子结构有关。
English
Synthesis and Bio-activity of Methyl-2-pyridinyl ketazine and Its Complexes with Co2+, Ni2+, Fe3+ and Zn2+
Abstract:
2-Acetyl-pyridin ketazine and its complexes with Co2+,Ni2+,Fe3+,Zn2+ were synthesized respectively by refluxing it with conresponding salts [FeCl3,CoCl2,Ni(NO3)2,ZnCl2].The compositions and structures of the ligand and complexes have been characterized by the elemental analysis,IR spectra and UV spectra.Their inhibiting actions on the superoxide anions were examined by using nitroblue tetrazolium (NBT) method.Their bioactivities against P388-leucocythemia for rats were tested by using methyl-thiazoltetrazolium (MTT) method and against A-549 human lung cancer cells by sulforhodamine B(SRB) method,both in vitro.The ligand and all of the complexes were found to be bioactive,while Co-and Nicomplexes showed greater activities and Fe- and Zn-complexes were weaker than the ligand.It is deduced that the activities of the complexes may depend on the structure of the outermost d-orbital electrons.
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Key words:
- ketazine
- / transition metal complex
- / synthesis
- / O2- inhibition
- / leucocythemia
- / lung cancer
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