引用本文:
胡国强, 邢勇, 张中泉, 陈百泉, 许启泰, 黄文龙, 张惠斌, 黄胜堂. 取代二噁二唑硫醚及砜衍生物合成及抗菌活性[J]. 应用化学,
2004, 21(6): 561-565.
Citation: HU Guo-Qiang, XING Yong, ZHANG Zhong-Quan, CHENG Bai-Quan, XU Qi-Tai, HUANG Wen-Long, ZHANG Hui-Bin, HUANG Sheng-Tang. Synthesis and Antibacterial Activity of Bisoxadiazole Sulfurether/Sulfone Derivatives[J]. Chinese Journal of Applied Chemistry, 2004, 21(6): 561-565.
Citation: HU Guo-Qiang, XING Yong, ZHANG Zhong-Quan, CHENG Bai-Quan, XU Qi-Tai, HUANG Wen-Long, ZHANG Hui-Bin, HUANG Sheng-Tang. Synthesis and Antibacterial Activity of Bisoxadiazole Sulfurether/Sulfone Derivatives[J]. Chinese Journal of Applied Chemistry, 2004, 21(6): 561-565.
取代二噁二唑硫醚及砜衍生物合成及抗菌活性
English
Synthesis and Antibacterial Activity of Bisoxadiazole Sulfurether/Sulfone Derivatives
Abstract:
Twenty 1,3,4-oxadiazole sulfurethers(3a~3j) and corresponding sulfone derivatives(4a~4j) were synthesized via condensation of 1,3,4-oxadiazole chloromethane(1) with the corresponding 1,3,4-oxadiazole thiols(2a~2j) followed by oxidation with 30% H2O2 in the presence of catalyst Na2WO4, and their structures were confirmed by IR, 1H NMR, MS and elemental analysis. Among the compounds synthesized, the sulfurether compounds (3b) and (3h) exhibited considerably strong inhibiting activity to Staphylococcus aureus and Proteus vulgaris in dosage of 1.0×10-4(mass fraction), the sulfone compounds 4b, 4c, 4d and 4f exhibited mediumly inhibiting activity to Escherichia.coli, whereas the other compounds showed weak or even no antibacterial activity.
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Key words:
- oxadiazole
- / sulfur ether
- / sulfone
- / antibacterial activity
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