Palladium-catalyzed ortho-selective C-H bond chlorination of aromatic ketones

Gang Shan Gui-Yi Huang Yu Rao Hui Zhang

Citation:  Gang Shan, Gui-Yi Huang, Yu Rao, Hui Zhang. Palladium-catalyzed ortho-selective C-H bond chlorination of aromatic ketones[J]. Chinese Chemical Letters, 2015, 26(10): 1236-1240. doi: 10.1016/j.cclet.2015.07.011 shu

Palladium-catalyzed ortho-selective C-H bond chlorination of aromatic ketones

    通讯作者: Yu Rao,
    Hui Zhang,
  • 基金项目:

    This work was supported by '973' grant (Nos. 2011CB965300) (Nos. 2011CB965300)

    NSFC (Nos. 21142008, 21302106) (Nos. 21142008, 21302106)

摘要: A palladium-catalyzed ortho-selective C-H bond chlorination reaction for the preparation of 2-chloro aromatic ketones was described. Both electron-withdrawing and electron-donating groups on the aromatic rings are well tolerated under the optimized conditions. The 2-chloro aromatic ketones obtained by our method could be applied to synthesize the derivatives of 1H-indazole or benzo[d]isoxazole.

English

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  • 发布日期:  2015-07-07
  • 收稿日期:  2015-04-25
  • 网络出版日期:  2015-06-24
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