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Efficient synthesis of 2-arylquinazolines via copper-catalyzed dual oxidative benzylic C-H aminations of methylarenes

Li-Yan Liu ,  Yi-Zhe Yan ,  Ya-Jie Bao ,  Zhi-Yong Wang

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Citation:  Li-Yan Liu, Yi-Zhe Yan, Ya-Jie Bao, Zhi-Yong Wang. Efficient synthesis of 2-arylquinazolines via copper-catalyzed dual oxidative benzylic C-H aminations of methylarenes[J]. Chinese Chemical Letters, 2015, 26(10): 1216-1220. doi: 10.1016/j.cclet.2015.07.008 shu

Efficient synthesis of 2-arylquinazolines via copper-catalyzed dual oxidative benzylic C-H aminations of methylarenes

    • 通讯作者: Zhi-Yong Wang,
  • 基金项目:

    We are grateful to the National Nature Science Foundation of China (Nos. 2127222, 91213303, 21172205, 21432009, 21472177). (Nos. 2127222, 91213303, 21172205, 21432009, 21472177)

摘要: A novel copper-catalyzed dual oxidative benzylic C-H aminations of methylarenes with 2- aminobenzoketones in the presence of ammonium acetate was developed. This reaction represents a new avenue for 2-arylquinazolines with good yields. A key intermediate was detected and the kinetics isotope effect (KIE) indicated that C-H bond cleavage was the rate-determining step.

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  • 发布日期:  2015-07-07
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