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Alumina-supported heteropoly acid: An effi cient catalyst for the synthesis of azaarene substituted 3-hydroxy-2-oxindole derivatives via C(sp3)H bond functionalization

Shuang-Hong Hao ,  Xue-Yan Zhang ,  Dao-Qing Dong ,  Zu-Li Wang

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Citation:  Shuang-Hong Hao, Xue-Yan Zhang, Dao-Qing Dong, Zu-Li Wang. Alumina-supported heteropoly acid: An effi cient catalyst for the synthesis of azaarene substituted 3-hydroxy-2-oxindole derivatives via C(sp3)H bond functionalization[J]. Chinese Chemical Letters, 2015, 26(5): 599-602. doi: 10.1016/j.cclet.2014.12.018 shu

Alumina-supported heteropoly acid: An effi cient catalyst for the synthesis of azaarene substituted 3-hydroxy-2-oxindole derivatives via C(sp3)H bond functionalization

    • 通讯作者: Zu-Li Wang,
  • 基金项目:

    Financial support from the National Natural Science Foundation of China (No. 21402103) (No. 21402103)

    the research fund of Qingdao Agricultural University’s High-level Person (No. 631303) (No. 631303)

    ing Young Scientist Award (No. BS2013YY024) were gratefully acknowledged. (No. BS2013YY024)

摘要: A method of C(sp3)-H bond functionalization of methyl azaarenes catalyzed by alumina-supported heteropoly acid and addition to isatins was developed. This transformation could be used for the synthesis of biologically important 3-hydroxy-2-oxindole derivatives in good to excellent yields and the catalyst could be reused for six times without significant decrease in activity.

English

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  • 发布日期:  2015-01-03
  • 收稿日期:  2014-01-08
  • 网络出版日期:  2014-12-10
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