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Potential anti-tubercular agents: Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones from anti-tubercular drug isoniazid and bis(substituted-benzylidene)cycloalkanones

Ayyakannu Arumugam Napoleon ,  Fazlur-Rahman Nawaz Khan ,  Euh Duck Jeong ,  Eun Hyuk Chung

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Citation:  Ayyakannu Arumugam Napoleon, Fazlur-Rahman Nawaz Khan, Euh Duck Jeong, Eun Hyuk Chung. Potential anti-tubercular agents: Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones from anti-tubercular drug isoniazid and bis(substituted-benzylidene)cycloalkanones[J]. Chinese Chemical Letters, 2015, 26(5): 567-571. doi: 10.1016/j.cclet.2015.01.008 shu

Potential anti-tubercular agents: Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones from anti-tubercular drug isoniazid and bis(substituted-benzylidene)cycloalkanones

    • 通讯作者: Fazlur-Rahman Nawaz Khan,
    Euh Duck Jeong,
摘要: A series of indazol-2-yl(pyridin-4-yl)methanones, 4 were acquired from 2,6-bisbenzylidene cyclohexanones, 3 and anti-tubercular drug (isoniazid), and their anti-tubercular impacts were screened. Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate alamar blue assay, the compounds 4g-j revealed moderate anti-tubercular activity with MIC 12.5 μg/mL, comparable to standard drugs (streptomycin, MIC, 6.25 μg/mL, pyrazinamide, isoniazid and ciprofloxacin with MICs of 3.125 μg/mL).

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  • 发布日期:  2015-01-12
  • 收稿日期:  2014-11-02
  • 网络出版日期:  2014-12-18
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