Design, synthesis, and insecticidal bioactivities evaluation of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring

注册 English

Design, synthesis, and insecticidal bioactivities evaluation of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring

Hong-Feng Shen , Xi Chen , Pin Liao , Xu-Shen Shao , Zhong Li , Xiao-Yong Xu

Citation: Hong-Feng Shen, Xi Chen, Pin Liao, Xu-Shen Shao, Zhong Li, Xiao-Yong Xu. Design, synthesis, and insecticidal bioactivities evaluation of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring[J]. Chinese Chemical Letters, 2015, 26(5): 509-512. doi: 10.1016/j.cclet.2015.03.017 shu

shu

Design, synthesis, and insecticidal bioactivities evaluation of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring

通讯作者: Xiao-Yong Xu,

基金项目:
This work was supported by National Key Technology R&D Program of China (No. 2011BAE06B01). (No. 2011BAE06B01)

摘要: Chlorothiazole ring, as a substituted heterocycle, frequently occurred in structures of various insecticides, and brought positive effect on bioactivity. In purpose to find novel neonicotinoids, a series of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring were synthesized for the first time. Results of the following biological assays showed that compounds 5a-c achieved good insecticidal activity against Aphis craccivora, and compound 5h exhibited good activity against Nilaparvata lugens.

关键词:

English

Design, synthesis, and insecticidal bioactivities evaluation of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring

1.
a Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;
2.
b Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai 200237, China

Corresponding author: Xiao-Yong Xu,

Received Date: 23 December 2014
Available Online: 28 March 2015
Fund Project:

Abstract: Chlorothiazole ring, as a substituted heterocycle, frequently occurred in structures of various insecticides, and brought positive effect on bioactivity. In purpose to find novel neonicotinoids, a series of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring were synthesized for the first time. Results of the following biological assays showed that compounds 5a-c achieved good insecticidal activity against Aphis craccivora, and compound 5h exhibited good activity against Nilaparvata lugens.

Key words:

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