Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing <i>s</i>-Triazole and Oxadiazole Subunits

引用本文: Guo Qiang HU, Sheng LI, Wen Long HUANG. Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits[J]. Chinese Chemical Letters, 2006, 17(7): 899-902. shu

Citation: Guo Qiang HU, Sheng LI, Wen Long HUANG. Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits[J]. Chinese Chemical Letters, 2006, 17(7): 899-902. shu

Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits

1.
Institute of Pharmacy, Henan Unversity, Kaifeng 475001;
2.
China Pharmaceutical University, Nanjing 210009
基金项目:
This project was supported by the State Basic Research and Development Project (No. G 1998051112) and the Science Foundation of Henan University (04ZDZR009).

摘要: 4-Amino-5-pyridin-4-yl-s-triazole-3-thiol (1) was sequentally reacted with 3-chloro-1-phenylpropan-1-one to afford 3-(4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl)-1-phenylpropan-1-one (2) followed by oximation with hydroxylamine hydrochloride and etherification with 5-aryl-[13,4]oxadiazole-2-chloromethanes to the corresponding oxime (3) and oxime-ethers (4a-e),respectively. The condensation of compounds 4 with salicylaldehyde gave the title compounds (5a-e). The antibacterial activity in vitro against Gram-postive (G⁺) and Gram negative (G^-)bacteria was primarily evaluated.

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English

Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits

1.
Institute of Pharmacy, Henan Unversity, Kaifeng 475001;
2.
China Pharmaceutical University, Nanjing 210009
Received Date: 11 January 2006
Fund Project:
This project was supported by the State Basic Research and Development Project (No. G 1998051112) and the Science Foundation of Henan University (04ZDZR009).

Abstract: 4-Amino-5-pyridin-4-yl-s-triazole-3-thiol (1) was sequentally reacted with 3-chloro-1-phenylpropan-1-one to afford 3-(4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl)-1-phenylpropan-1-one (2) followed by oximation with hydroxylamine hydrochloride and etherification with 5-aryl-[13,4]oxadiazole-2-chloromethanes to the corresponding oxime (3) and oxime-ethers (4a-e),respectively. The condensation of compounds 4 with salicylaldehyde gave the title compounds (5a-e). The antibacterial activity in vitro against Gram-postive (G⁺) and Gram negative (G^-)bacteria was primarily evaluated.

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits

English

Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits

English

Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

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