引用本文:
Ye WANG, Zhan Zhu LIU, Ye Feng TANG, Shi Zhi CHEN. An Efficient Synthetic Strategy for Construction of Functionalized Pentacyclic Skeleton of ecteinascidin-saframycin Alkaloids[J]. Chinese Chemical Letters,
2006, 17(7): 853-856.
Citation: Ye WANG, Zhan Zhu LIU, Ye Feng TANG, Shi Zhi CHEN. An Efficient Synthetic Strategy for Construction of Functionalized Pentacyclic Skeleton of ecteinascidin-saframycin Alkaloids[J]. Chinese Chemical Letters, 2006, 17(7): 853-856.
Citation: Ye WANG, Zhan Zhu LIU, Ye Feng TANG, Shi Zhi CHEN. An Efficient Synthetic Strategy for Construction of Functionalized Pentacyclic Skeleton of ecteinascidin-saframycin Alkaloids[J]. Chinese Chemical Letters, 2006, 17(7): 853-856.
An Efficient Synthetic Strategy for Construction of Functionalized Pentacyclic Skeleton of ecteinascidin-saframycin Alkaloids
摘要:
Two functionalized pentacyclic compounds 12a, 12b were constructed via a highly efficient synthetic route, employing a tricyclic amino aldehyde as the key intermediate. The crucial steps involved coupling of two segments via amide bond, Swern oxidation and intramolecular Pictet-Spengler cyclization.
English
An Efficient Synthetic Strategy for Construction of Functionalized Pentacyclic Skeleton of ecteinascidin-saframycin Alkaloids
Abstract:
Two functionalized pentacyclic compounds 12a, 12b were constructed via a highly efficient synthetic route, employing a tricyclic amino aldehyde as the key intermediate. The crucial steps involved coupling of two segments via amide bond, Swern oxidation and intramolecular Pictet-Spengler cyclization.
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Key words:
- Ecteinascidin
- / saframycin
- / tetrahydroisoquinoline
- / Pictet-Spengler reaction
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