引用本文:
Zheng Bang LI, Qiao Hong CHEN, Feng Peng WANG, Bo Gang LI. Oxidation of the Norditerpenoid Alkaloids Isotalatizidine and 6-Epiforsticine[J]. Chinese Chemical Letters,
2000, 11(5): 421-424.
Citation: Zheng Bang LI, Qiao Hong CHEN, Feng Peng WANG, Bo Gang LI. Oxidation of the Norditerpenoid Alkaloids Isotalatizidine and 6-Epiforsticine[J]. Chinese Chemical Letters, 2000, 11(5): 421-424.

Citation: Zheng Bang LI, Qiao Hong CHEN, Feng Peng WANG, Bo Gang LI. Oxidation of the Norditerpenoid Alkaloids Isotalatizidine and 6-Epiforsticine[J]. Chinese Chemical Letters, 2000, 11(5): 421-424.

Oxidation of the Norditerpenoid Alkaloids Isotalatizidine and 6-Epiforsticine
摘要:
Oxidation of 1 with KMnO4 in acetone-H2O (1:1) for 1h gave nevadenine 2 (38%). But, 3 was formed in 98% yield when prolonging time and raising temperature (40℃). Reaction of 1 and 10 with Conforth reagent afforded the ketones 11 (55%), 12 (30%), and 13 (13%), 14 (20%), respectively. While oxidation of 7 and 15 with a variety of the oxidizing agents gave 17 only in low 20% of yield besides the minor 16. In addition, 1 was converted to 2 by the fungi Curvularia lunata.
English
Oxidation of the Norditerpenoid Alkaloids Isotalatizidine and 6-Epiforsticine
Abstract:
Oxidation of 1 with KMnO4 in acetone-H2O (1:1) for 1h gave nevadenine 2 (38%). But, 3 was formed in 98% yield when prolonging time and raising temperature (40℃). Reaction of 1 and 10 with Conforth reagent afforded the ketones 11 (55%), 12 (30%), and 13 (13%), 14 (20%), respectively. While oxidation of 7 and 15 with a variety of the oxidizing agents gave 17 only in low 20% of yield besides the minor 16. In addition, 1 was converted to 2 by the fungi Curvularia lunata.
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Key words:
- Norditerpenoid alkaloid
- / oxidation
- / isotalatizidine
- / 6-epiforsticine
- / Curvularia lunata

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