引用本文:
Ying Wu Lin, Tian Lei Ying, Li Fu Liao. Dynamic consequences of mutating the typical HPGG motif of apocytochrome b5 revealed by computer simulation[J]. Chinese Chemical Letters,
2009, 20(5): 631-634.
doi:
10.1016/j.cclet.2009.01.037
Citation: Ying Wu Lin, Tian Lei Ying, Li Fu Liao. Dynamic consequences of mutating the typical HPGG motif of apocytochrome b5 revealed by computer simulation[J]. Chinese Chemical Letters, 2009, 20(5): 631-634. doi: 10.1016/j.cclet.2009.01.037
Citation: Ying Wu Lin, Tian Lei Ying, Li Fu Liao. Dynamic consequences of mutating the typical HPGG motif of apocytochrome b5 revealed by computer simulation[J]. Chinese Chemical Letters, 2009, 20(5): 631-634. doi: 10.1016/j.cclet.2009.01.037
Dynamic consequences of mutating the typical HPGG motif of apocytochrome b5 revealed by computer simulation
摘要:
Apocytochrome b5 with a typical heme-binding motif of HPGG, and its variants with mutated motifs, GPGG, GPGH, HVGG,and HPGP, have been subjected to molecular dynamics simulation. Comparison of the dynamic consequences has revealed the crucial role of HPGG in assembling the heme group of cytochrome b5 and in modulating protein structure, property and function.
English
Dynamic consequences of mutating the typical HPGG motif of apocytochrome b5 revealed by computer simulation
Abstract:
Apocytochrome b5 with a typical heme-binding motif of HPGG, and its variants with mutated motifs, GPGG, GPGH, HVGG,and HPGP, have been subjected to molecular dynamics simulation. Comparison of the dynamic consequences has revealed the crucial role of HPGG in assembling the heme group of cytochrome b5 and in modulating protein structure, property and function.
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Key words:
- Apocytochrome b5
- / Heme-binding motif
- / HPGG
- / Molecular dynamics simulation
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