引用本文:
Paresh N. Patel, Khyati D. Patel, Hasmukh S. Patel. Synthesis and biological study of novel 5-{(4-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)-methyl}-quinolin-8-ol and its metal complexes[J]. Chinese Chemical Letters,
2011, 22(11): 1297-1230.
doi:
10.1016/j.cclet.2011.05.042
Citation: Paresh N. Patel, Khyati D. Patel, Hasmukh S. Patel. Synthesis and biological study of novel 5-{(4-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)-methyl}-quinolin-8-ol and its metal complexes[J]. Chinese Chemical Letters, 2011, 22(11): 1297-1230. doi: 10.1016/j.cclet.2011.05.042
Citation: Paresh N. Patel, Khyati D. Patel, Hasmukh S. Patel. Synthesis and biological study of novel 5-{(4-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)-methyl}-quinolin-8-ol and its metal complexes[J]. Chinese Chemical Letters, 2011, 22(11): 1297-1230. doi: 10.1016/j.cclet.2011.05.042
Synthesis and biological study of novel 5-{(4-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)-methyl}-quinolin-8-ol and its metal complexes
摘要:
A novel 5-( (4-(6, 7-dihydrothieno[3, 2-c]pyridin-5 (4H)-ylsulfonyl)phenylamino)methyl)quinolin-8-ol (HTPSMQol) was synthesized by optimized reaction of 4-(6, 7-dihydrothieno[3, 2-c]pyridin-5 (4H)-ylsulfonyl)aniline with 5-chloromethyI-8-hydroxy_quinoline hydrochloride (CMHQ). Also complexes of HTPSMQol were prepared by using various M (Ⅱ) metal salts. All compounds were analyzed by spectroscopic techniques and screened against various strains of microorganisms. The results showed higher antimicrobial activity of HTPSMQol compared to its metal complexes and comparable with Ciprofloxacin.
English
Synthesis and biological study of novel 5-{(4-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)-methyl}-quinolin-8-ol and its metal complexes
Abstract:
A novel 5-((4-(6, 7-dihydrothieno[3, 2-c]pyridin-5(4H)-ylsulfonyl)phenylamino)methyl)quinolin-8-ol (HTPSMQol) was synthesized by optimized reaction of 4-(6, 7-dihydrothieno[3, 2-c]pyridin-5(4H)-ylsulfonyl)aniline with 5-chloromethyI-8-hydroxy_quinoline hydrochloride (CMHQ). Also complexes of HTPSMQol were prepared by using various M (Ⅱ) metal salts. All compounds were analyzed by spectroscopic techniques and screened against various strains of microorganisms. The results showed higher antimicrobial activity of HTPSMQol compared to its metal complexes and comparable with Ciprofloxacin.
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