水介质中药物-AOT混合物的温度依赖的混合胶束化行为

引用本文: RUB Malik Abdul, ASIRI Abdullah M, KUMAR Dileep, AZUM Naved, KHAN Farah. 水介质中药物-AOT混合物的温度依赖的混合胶束化行为[J]. 物理化学学报, 2014, 30(4): 699-707. doi: 10.3866/PKU.WHXB201402112 shu

Citation: RUB Malik Abdul, ASIRI Abdullah M, KUMAR Dileep, AZUM Naved, KHAN Farah. Temperature Dependant Mixed Micellization Behavior of a Drug-AOT Mixture in an Aqueous Medium[J]. Acta Physico-Chimica Sinica, 2014, 30(4): 699-707. doi: 10.3866/PKU.WHXB201402112 shu

水介质中药物-AOT混合物的温度依赖的混合胶束化行为

基金项目:
The project was supported by the Chemistry Department and Centre of Excellence for Advanced Materials Research, King Abdulaziz University,Jeddah, Saudi Arabia.

摘要:

The mixed micellization behavior of an amphiphilic antidepressant drug amitriptyline hydrochloride (AMT) in the presence of the conventional anionic surfactant sodium bis(2-ethylhexyl) sulfosuccinate (AOT) was studied at five different temperatures and compositions by the conductometric technique. The critical micelle concentration (cmc) and critical micelle concentration at the ideal state (cmc^id) values show mixed micelle formation between the components (i.e., drug and AOT). The micellar mole fractions of the AOT (X₁) values calculated using the Rubingh, Motomura, and Rodenas models show a higher contribution of AOT in the mixed micelles. The interaction parameter (β) is negative at all temperatures and the compositions show attractive interactions between the components. The activity coefficients (f₁ and f₂) calculated using the different proposed models are always less than unity indicating non-ideality in the systems. The ΔG_m^θ values were found to be negative for all the binary mixed systems. However, ΔH_m^θ values for the pure drug as well as the drug-AOT mixed systems are negative at lower temperatures (293.15-303.15 K) and positive at higher temperatures (308.15 K and above). The ΔS_m^θ values are positive at all temperatures but their magnitude was higher at T=308.15 K and above. The excess free energy of mixing (ΔG_ex) determined using the different proposed models also explains the stability of the mixed micelles compared to the pure drug (AMT) and surfactant micelles.

关键词:

English

Temperature Dependant Mixed Micellization Behavior of a Drug-AOT Mixture in an Aqueous Medium

1.
1 Chemistry Department, King Abdulaziz University, Jeddah-21589, Saudi Arabia;
2 Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah-21589, Saudi Arabia;
3 Department of Chemistry, Aligarh Muslim University, Aligarh-202002, India
Received Date: 06 December 2013
Available Online: 31 March 2014
Fund Project:
The project was supported by the Chemistry Department and Centre of Excellence for Advanced Materials Research, King Abdulaziz University,Jeddah, Saudi Arabia.

Abstract:

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

水介质中药物-AOT混合物的温度依赖的混合胶束化行为

English

Temperature Dependant Mixed Micellization Behavior of a Drug-AOT Mixture in an Aqueous Medium

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中国化学会秘书处

水介质中药物-AOT混合物的温度依赖的混合胶束化行为

English

Temperature Dependant Mixed Micellization Behavior of a Drug-AOT Mixture in an Aqueous Medium

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

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