超分子化学在本科实验中的运用——六元瓜环对氨基苯酚同分异构体的新型分离方法

引用本文: 林文浩, 刘明, 杨茂霞, 张佳怡, 王成会, 肖昕. 超分子化学在本科实验中的运用——六元瓜环对氨基苯酚同分异构体的新型分离方法[J]. 大学化学, 2023, 38(4): 260-268. doi: 10.3866/PKU.DXHX202210088 shu

Citation: Wenhao Lin, Ming Liu, Maoxia Yang, Jiayi Zhang, Chenghui Wang, Xin Xiao. Application of Supramolecular Chemistry in Undergraduate Laboratory: A New Method for Separation of Aminophenol Isomers by Cucurbit[6]uril[J]. University Chemistry, 2023, 38(4): 260-268. doi: 10.3866/PKU.DXHX202210088 shu

超分子化学在本科实验中的运用——六元瓜环对氨基苯酚同分异构体的新型分离方法

贵州大学化学与化工学院, 贵州省大环化学与超分子化学重点实验室, 贵阳 550025
基金项目:
贵州省大学生创新创业训练计划项目(202110657017)；贵州大学研究生课程思政示范课程项目(KCSZ2022033)

摘要: 基于“厚基础，宽专业，大综合”的研究型实验教学思想，本文在本科教学实验中融入超分子化学理论知识，设计创新综合实验。选取六元瓜环为主体，运用超分子自组装原理实现邻、间、对氨基苯酚同分异构体选择性梯度分离，分离纯度分别达91.46%、94.16%、96.70%。整个实验中主要原料均可回收再利用，充分体现了绿色化学理念。同时，本实验使用多种化学实验的基本操作，包含薄层色谱法、液相色谱法、红外光谱法等重要分析手段对目标产物进行分离进程监测、纯度分析与结构表征，能够使学生结合基础理论知识解释实验原理、分析实验现象，进一步提升学生的研究型素养和综合运用知识的能力。

关键词:

English

Application of Supramolecular Chemistry in Undergraduate Laboratory: A New Method for Separation of Aminophenol Isomers by Cucurbit[6]uril

Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, China
Received Date: 27 October 2022

Abstract: Based on the research-oriented laboratory teaching concept of “thick foundation, wide professional, and comprehensive”, this paper combines the theoretical knowledge of supramolecular chemistry and macrocyclic chemistry to design a new comprehensive experiment of selective gradient separation of o-, m-, p-aminophenol isomers with the purity of 91.46%, 94.16% and 96.70%, respectively, based on supramolecular self-assembly using cucurbit[6]uril as the host. All reagents can be recycled after the experiment, fully embodying the concept of green chemistry. This experiment involves TLC, LC, IR, and other important analytical methods to monitor the separation process, purity analysis, and structural characterization of the target product, which enables students to fully master basic theoretical knowledge, experimental principles, and learn to analyze experimental phenomena, thereby improving students’ research-oriented literacy and ability to comprehensively apply knowledge.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

超分子化学在本科实验中的运用——六元瓜环对氨基苯酚同分异构体的新型分离方法

English

Application of Supramolecular Chemistry in Undergraduate Laboratory: A New Method for Separation of Aminophenol Isomers by Cucurbit[6]uril

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

超分子化学在本科实验中的运用——六元瓜环对氨基苯酚同分异构体的新型分离方法

English

Application of Supramolecular Chemistry in Undergraduate Laboratory: A New Method for Separation of Aminophenol Isomers by Cucurbit[6]uril

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs