以氧化锌为锌源的手性金属-有机骨架的合成及其用于联糠醛外消旋体的选择性吸附

引用本文: 王翠杰, 高煜, 李星林, 赵无垛, 于阿娟, 张书胜. 以氧化锌为锌源的手性金属-有机骨架的合成及其用于联糠醛外消旋体的选择性吸附[J]. 色谱, 2020, 38(5): 516-521. doi: 10.3724/SP.J.1123.2019.10024 shu

Citation: WANG Cuijie, GAO Yu, LI Xinglin, ZHAO Wuduo, YU Ajuan, ZHANG Shusheng. Synthesis of a chiral metal-organic framework using zinc oxide as zinc source for enantioselective adsorption of 2,2'-furoin racemate[J]. Chinese Journal of Chromatography, 2020, 38(5): 516-521. doi: 10.3724/SP.J.1123.2019.10024 shu

以氧化锌为锌源的手性金属-有机骨架的合成及其用于联糠醛外消旋体的选择性吸附

王翠杰 ^1, ,
高煜 ^1, ,
李星林 ^1, ,
赵无垛 ^2, ,
于阿娟 ^{1,
,} ,
张书胜 ^{1,2,
,}

1.
郑州大学化学学院, 河南郑州 450001;
2.
现代分析与基因测序中心, 河南郑州 450001

通讯作者: 于阿娟, E-mail:yuajuan@zzu.edu.cn; 张书胜, E-mail:zsszz@126.com

基金项目:
国家自然科学基金（21675144，21775140，21705143）.

摘要: 通过使用氧化锌代替传统的金属无机盐为锌源，制备了手性金属-有机骨架（CMOF）[Zn（L-mal）（H₂O）₂]_n并对其手性分离性能进行了考察。将ZnO和L-苹果酸按物质的量之比1：1溶于水中，在室温下静置24 h即可得到[Zn（L-mal）（H₂O）₂]_n。以100 mg[Zn（L-mal）（H₂O）₂]_n为吸附剂，将250 μL 1 g/L的联糠醛外消旋体加入其中，并以4.5 mL异丙醇和1 mL甲醇为萃取剂和洗脱剂进行选择性吸附实验，最终滤液使用高效液相色谱仪（HPLC）进行分析。结果表明，[Zn（L-mal）（H₂O）₂]_n对R-联糠醛具有较好的选择性吸附，其对映体过量（ee）值为20%。该工作为CMOF的绿色制备提供了一定的方法和经验并拓展了其在手性分离领域的应用。

关键词:

English

Synthesis of a chiral metal-organic framework using zinc oxide as zinc source for enantioselective adsorption of 2,2'-furoin racemate

WANG Cuijie ^1, ,
GAO Yu ^1, ,
LI Xinglin ^1, ,
ZHAO Wuduo ^2, ,
YU Ajuan ^{1,
,} ,
ZHANG Shusheng ^{1,2,
,}

1.
College of Chemistry, Zhengzhou University, Zhengzhou 450001, China;
2.
The Center of Advanced Analysis and Gene Sequencing, Zhengzhou 450001, China

Corresponding author: YU Ajuan, ; ZHANG Shusheng,

Received Date: 24 October 2019
Fund Project:
National Natural Science Foundation of China (Nos. 21675144, 21775140, 21705143).

Abstract: Chiral metal-organic frameworks (CMOFs),[Zn(L-mal)(H₂O)₂]_n were prepared by using zinc oxide instead of the traditional metal inorganic salt as the zinc source, and their chiral separation performance was investigated. Equal amounts of ZnO and L-malic acid were dissolved in H₂O, and[Zn(L-mal)(H₂O)₂]_n were obtained by allowing the mixture to stand at room temperature for 24 h. Then, 100 mg[Zn(L-mal)(H₂O)₂]_n as the adsorbent was added to 250 μL 1 g/L 2,2'-furoin racemate, and 4.5 mL isopropanol and 1 mL methanol were selected as the extraction solvent and elution solvent, respectively, for selective adsorption experiments. The final filtrate was analyzed by high performance liquid chromatography (HPLC). The results showed that[Zn(L-mal)(H₂O)₂]_n exhibited better selective adsorption ability for R-2,2'-furoin with 20% enantiomeric excess (ee). This work provides a new method for the green preparation of CMOF and expands its application in the field of chiral separation.

Key words:

chiral separation
/ chiral metal-organic frameworks (CMOF)
/ zinc oxide
/ 2,2'-furoin racemate

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沈阳化工大学材料科学与工程学院沈阳 110142

以氧化锌为锌源的手性金属-有机骨架的合成及其用于联糠醛外消旋体的选择性吸附

通讯作者: 于阿娟, E-mail:yuajuan@zzu.edu.cn; 张书胜, E-mail:zsszz@126.com

English

Synthesis of a chiral metal-organic framework using zinc oxide as zinc source for enantioselective adsorption of 2,2'-furoin racemate

Corresponding author: YU Ajuan, ; ZHANG Shusheng,

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中国化学会秘书处

以氧化锌为锌源的手性金属-有机骨架的合成及其用于联糠醛外消旋体的选择性吸附

通讯作者: 于阿娟, E-mail:yuajuan@zzu.edu.cn; 张书胜, E-mail:zsszz@126.com

English

Synthesis of a chiral metal-organic framework using zinc oxide as zinc source for enantioselective adsorption of 2,2'-furoin racemate

Corresponding author: YU Ajuan, ; ZHANG Shusheng,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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