糖芯片制备和应用的最新研究进展

引用本文: 万锕俊, 王琨, 张洪才, 李慧丽, 王德农. 糖芯片制备和应用的最新研究进展[J]. 分析化学, 2012, 40(11): 1780-1788. doi: 10.3724/SP.J.1096.2012.20448 shu

Citation: WAN A-Jun, WANG Kun, ZHANG Hong-Cai, LI Hui-Li, WANG De-Nong. Modern Carbohydrate Microarray Bio-chip Technologies[J]. Chinese Journal of Analytical Chemistry, 2012, 40(11): 1780-1788. doi: 10.3724/SP.J.1096.2012.20448 shu

糖芯片制备和应用的最新研究进展

万锕俊 ^{1,
,} ,
王琨 ^2, ,
张洪才 ^1,2, ,
李慧丽 ^3, ,
王德农 ^{4,
,}

通讯作者: 万锕俊, 王德农; 万锕俊, 王德农

基金项目:
本文系中国国家自然科学基金项目(No. 51173104) (No. 51173104)

上海纳米专项(No. 11nm0503500) (No. 11nm0503500)

美国NIH基金项目(No. CA128416)资助 (No. CA128416)

摘要: 糖芯片是一种研究微量糖与生物大分子之间相互作用的生物检测技术,因其具有用量少、快速、高效和高通量等特点,现已被广泛应用到药物开发、免疫学、临床诊断和细菌检测等诸多领域中。近年来,尽管对糖芯片的制备方法和应用进行了较为深入的研究,但对糖芯片的制备方法和应用的综述还较少报道。本文主要介绍糖芯片的制备原理、非化学修饰和化学修饰制备糖芯片的最新方法,然后对糖芯片在自组装等方面应用的最新进展进行综述,并对糖芯片所遇到的挑战和发展趋势也作了展望。

关键词:

微阵列
/ 生物芯片
/ 糖芯片
/ 自组装
/ 综述

English

Modern Carbohydrate Microarray Bio-chip Technologies

1.
¹ School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;

Corresponding author: 万锕俊, 王德农; 万锕俊, 王德农

Received Date: 27 April 2012
Fund Project:
本文系中国国家自然科学基金项目(No. 51173104)

上海纳米专项(No. 11nm0503500)

美国NIH基金项目(No. CA128416)资助

Abstract: Carbohydrate microarray (glyco-chip), is one of modern biotechnologies for monitoring the molecular interactions between carbohydrate ligands and other biomacromolecules. It is characterized by micro-scale, quickness, high sensitivity and high-throughput and is widely applicable in many fields. Its promising R & D areas include, but are not limited to, biology, basic medical research, clinical diagnostics, drug development and bio-material & reagent industry. This article intends to summarize methods that are currently used for the construction of glyco-chips, such as immobilization of either chemically modified or non-modified carbohydrates and procedures of self-assembly for production of three-dimensional glyco-chips. Current challenges and future trends in the R & D of glyco-chips are also discussed.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

糖芯片制备和应用的最新研究进展

通讯作者: 万锕俊, 王德农; 万锕俊, 王德农

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Corresponding author: 万锕俊, 王德农; 万锕俊, 王德农

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

糖芯片制备和应用的最新研究进展

通讯作者: 万锕俊, 王德农; 万锕俊, 王德农

English

Modern Carbohydrate Microarray Bio-chip Technologies

Corresponding author: 万锕俊, 王德农; 万锕俊, 王德农

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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