注册 English

氢键促进对乙酰氨基酚在模拟细胞膜表面的富集

李霞 ,  陈壮壮 ,  范爱华 ,  张丽丽 ,  邵会波

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引用本文: 李霞, 陈壮壮, 范爱华, 张丽丽, 邵会波. 氢键促进对乙酰氨基酚在模拟细胞膜表面的富集[J]. 分析化学, 2022, 50(9): 1364-1372. doi: 10.19756/j.issn.0253-3820.221012 shu
Citation:  LI Xia,  CHEN Zhuang-Zhuang,  FAN Ai-Hua,  ZHANG Li-Li,  SHAO Hui-Bo. Accumulation of Paracetamol on Surface of Simulated Cell Membrane Promoted by Hydrogen Bonding[J]. Chinese Journal of Analytical Chemistry, 2022, 50(9): 1364-1372. doi: 10.19756/j.issn.0253-3820.221012 shu

氢键促进对乙酰氨基酚在模拟细胞膜表面的富集

  • 北京理工大学化学与化工学院, 北京 102488

    • 通讯作者: 邵会波,E-mail:hbs@bit.edu.cn
  • 基金项目:

    国家自然科学基金项目（No.21872006）资助。

摘要: 广谱解热镇痛药物扑热息痛(对乙酰氨基酚,APAP)在细胞膜表面借助于氢键促进的富集对其发挥药效作用非常重要。本研究以表面含有氢受体(荷负电的羧酸根)的3-巯基丙酸自组装膜(MPA SAM)作为模拟细胞膜表面的简化模型,通过扫描电化学显微镜(SECM)方法研究了氢键促进的APAP在模拟细胞膜表面的富集作用。实验结果表明,随着Mg2+浓度的增大或pH值的升高,MPA SAM表面羧基解离平衡正向移动,产生了更多的羧酸根(氢受体),促进了APAP在MPA SAM表面的富集。采用SECM成像模式实现了上述富集过程的可视化考察。本研究对理解APAP在生物膜表面借助于氢键的富集过程以及APAP传感器的设计提供了参考。

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  • 收稿日期:  2022-01-08
  • 修回日期:  2022-04-03
通讯作者: 陈斌, bchen63@163.com
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