稀土上转换纳米材料在microRNAs检测中的应用

引用本文: 罗达, 张毅, 杨晓雯, 程芳芳, 张丽. 稀土上转换纳米材料在microRNAs检测中的应用[J]. 分析化学, 2021, 49(9): 1428-1436. doi: 10.19756/j.issn.0253-3820.211186 shu

Citation: LUO Da, ZHANG Yi, YANG Xiao-Wen, CHENG Fang-Fang, ZHANG Li. Application of Up-conversion Nanomaterials in Detection of MicroRNAs[J]. Chinese Journal of Analytical Chemistry, 2021, 49(9): 1428-1436. doi: 10.19756/j.issn.0253-3820.211186 shu

稀土上转换纳米材料在microRNAs检测中的应用

南京中医药大学, 江苏省中药资源产业化过程协同创新中心中药资源产业化与方剂创新药物国家地方联合工程研究中心, 南京 210023

通讯作者: 程芳芳,E-mail:ffcheng@njucm.edu.cn; 张丽,E-mail:zhangli@njucm.edu.cn

基金项目:
国家自然科学基金项目（No.21705081）、江苏省自然科学基金项目（Nos.BK20161037，BK20201232）和江苏省333高层次人才项目（No.BRA2020071）资助。

摘要: 在疾病的发生与发展过程中，常伴随着某些microRNAs的异常表达。microRNAs是一类非编码的小RNA分子，可以作为基因表达的后转录调节因子，在一些基本的生理和病理过程中发挥作用。研究表明，microRNAs可以作为生物标志物，用于疾病的诊断与治疗。传统的microRNAs检测方法存在灵敏度低、选择性差等缺点，难以实现在体实时检测。稀土上转换纳米材料具有独特的反斯托克斯位移性质，并且抗光漂白性好、组织自发荧光干扰小、生物相容性好、毒性小，已被广泛用于体内外microRNAs的检测。因此，通过稀土上转换纳米材料实时监测体内外microRNAs表达水平的变化，可以动态掌握疾病的发生与发展过程，为疾病的诊疗和预后提供依据。本文综述了近年来稀土上转换纳米材料在microRNAs检测中的应用研究进展。

关键词:

English

Application of Up-conversion Nanomaterials in Detection of MicroRNAs

Jiangsu Provincial Collaborative Innovation Center for Industrialization Process of Traditional Chinese Medicine Resources/National-Local Joint Engineering Research Center for Traditional Chinese Medicine Resources Industrialization, Prescriptions and Innovative Drugs, Nanjing University of Chinese Medicine, Nanjing 210023, China

Corresponding author: CHENG Fang-Fang, ; ZHANG Li,

Received Date: 15 March 2021
Revised Date: 06 June 2021
Fund Project:
Supported by the National Natural Science Foundation of China (No.21705081), the Natural Science Foundation of Jiangsu Province, China (Nos.BK20161037, BK20201232) and the 333 High-level Talents Training Project Funded by Jiangsu Province, China (No.BRA2020071).

Abstract: The occurrence and development of diseases are often accompanied by abnormal expression of certain microRNAs. MicroRNAs are small and non-coding RNA molecules which play an important role in many basic physiological and pathological processes as post-transcriptional regulators of gene expression. At present, many studies have shown that microRNAs can be used as biomarkers for diagnosis and treatment of diseases. Traditional detection methods of microRNAs often have shortcomings such as low sensitivity and poor selectivity, and cannot achieve real-time detection. Rare earth upconversion nanomaterials have unique anti-stokes shift properties and advantages including good photobleaching resistance, low tissue autofluorescence interference, good biocompatibility and low toxicity, and thus are commonly used for microRNAs detection. Therefore, detecting the changes of expression level of microRNAs using up-conversion nanomaterials in real-time can identify the occurrence and development of diseases, and provide evidence for the diagnosis, treatment and prognosis of diseases. In this papar, the application progress of up-conversion nanomaterials in detection of microRNAs in recent years is reviewed.

Key words:

Rare earth up-conversion nanomaterials
/ MicroRNAs
/ Photoluminescence
/ Fluorescence resonance energy transfer
/ Ratiometric fluorescence
/ Review

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

稀土上转换纳米材料在microRNAs检测中的应用

通讯作者: 程芳芳,E-mail:ffcheng@njucm.edu.cn; 张丽,E-mail:zhangli@njucm.edu.cn

English

Application of Up-conversion Nanomaterials in Detection of MicroRNAs

Corresponding author: CHENG Fang-Fang, ; ZHANG Li,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

稀土上转换纳米材料在microRNAs检测中的应用

通讯作者: 程芳芳,E-mail:ffcheng@njucm.edu.cn; 张丽,E-mail:zhangli@njucm.edu.cn

English

Application of Up-conversion Nanomaterials in Detection of MicroRNAs

Corresponding author: CHENG Fang-Fang, ; ZHANG Li,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs