印刷电路板离子阱偶极共振激发电场的理论模拟及性能优化

引用本文: 朱雯飞, 吴辉, 葛赛金, 张英军, 姚如娇, 蒋公羽, 肖育, 李晓旭. 印刷电路板离子阱偶极共振激发电场的理论模拟及性能优化[J]. 分析化学, 2021, 49(5): 693-701. doi: 10.19756/j.issn.0253-3820.211011 shu

Citation: ZHU Wen-Fei, WU Hui, GE Sai-Jin, ZHANG Ying-Jun, YAO Ru-Jiao, JIANG Gong-Yu, XIAO Yu, LI Xiao-Xu. Optimization of Resonant Excitation Electric Field in Discrete Electrode Printed Circuit Board Ion Trap Mass Analyzer[J]. Chinese Journal of Analytical Chemistry, 2021, 49(5): 693-701. doi: 10.19756/j.issn.0253-3820.211011 shu

印刷电路板离子阱偶极共振激发电场的理论模拟及性能优化

朱雯飞 ^1, ,
吴辉 ^1, ,
葛赛金 ^1, ,
张英军 ^1, ,
姚如娇 ^2, ,
蒋公羽 ^2, ,
肖育 ^{2,
,} ,
李晓旭 ^{1,
,}

1.
苏州大学机电工程学院, 苏州 215021;
2.
上海卫星装备研究所, 上海 200240

通讯作者: 肖育,E-mail:xxli@suda.edu.cn; 李晓旭,E-mail:xiaoyush812@126.com

基金项目:
国家自然科学基金项目（No.61971297）和上海市自然科学基金项目（No.19ZR1478000）资助。

摘要: 印刷电路板离子阱（Printed circuit board ion trap，PCBIT）是一种简化电极结构的线形离子阱质量分析器，其独特的离散电极结构使其内部电场可通过改变电压施加方式进行优化，从而提高其分析性能。现有的研究多集中在PCBIT的主射频电场的优化。为进一步提升PCBIT的分析性能，本研究提出了在优化主射频电场的同时，对其共振激发电场进行优化的方法。首先，分析了几何结构对离子阱内部主射频电场分布及质量分辨率的影响；然后，选取优化主射频电场后的PCBIT，通过改变其偶极共振激发信号的电压施加方式，优化离子阱内部共振激发电场，并对离子运动轨迹进行模拟和仿真，以评估和分析PCBIT的分析性能。优化共振激发电场的具体方法主要是在PCBIT的X方向离散电极上施加不同分压比的偶极共振激发信号。模拟结果表明，仅优化主射频电场对PCBIT的质量分辨率的提升效果并不明显，但同时优化主射频电场和共振激发电场可显著提高PCBIT的质量分辨率。在优化的几何结构和参数条件下，当PCBIT的偶极共振激发信号分压比为2%时，m/z 1891离子质谱峰的质量分辨率可达到14500。本研究提出的优化方法可在不改变PCBIT几何结构的情况下，仅通过优化偶极共振激发信号的施加方式，实现共振激发电场的优化，进而大幅提升PCBIT的质量分辨率，为研制高性能小型化线形离子阱质谱分析仪提供了一种新方法。

关键词:

English

Optimization of Resonant Excitation Electric Field in Discrete Electrode Printed Circuit Board Ion Trap Mass Analyzer

ZHU Wen-Fei ^1, ,
WU Hui ^1, ,
GE Sai-Jin ^1, ,
ZHANG Ying-Jun ^1, ,
YAO Ru-Jiao ^2, ,
JIANG Gong-Yu ^2, ,
XIAO Yu ^{2,
,} ,
LI Xiao-Xu ^{1,
,}

1.
School of Mechatronic Engineering, Soochow University, Suzhou 215021, China;
2.
Institute of Spacecraft Equipment, Shanghai 200240, China

Corresponding author: XIAO Yu, ; LI Xiao-Xu,

Received Date: 07 January 2021
Revised Date: 09 March 2021
Fund Project:
Supported by the National Science Foundation of China (No.61971297) and the National Science Foundation of Shanghai, China (No.19ZR1478000).

Abstract: The printed circuit board ion trap (PCBIT) is a mass analyzer with a unique discrete electrode structure, so the electric fields inside could be flexibly adjusted. Previous researches of PCBIT mainly concentrated on the optimization of the radio-frequency (RF) electric fields, which was usually realized by modifying the geometric parameters or the voltage divided ratio of RF voltage (α). In this work, a new method was proposed to further improve the performance of PCBIT. That is, the resonant excitation electric field was optimized in company with the geometric parameters of PCBIT. During the simulation, the geometric parameters of PCBIT were firstly modified to optimize the internal RF electric fields, seeking for greater mass resolution. Then the resonant excitation electric field was optimized by adjusting voltage divided ratio of resonant excitation signal (γ). And the ion trajectories and simulated mass spectrum were also calculated. The results showed that it could be impossible to improve mass resolution significantly by optimizing the RF electric fields only, while the optimization of resonant excitation field could significantly improve the mass resolution. To achieve great analysis performance, the γ value should be set up at a relatively low level. For ions at m/z 1891 Da, the optimal mass resolution of over 14500 (FWHM) was obtained in an optimized PCBIT with γ=2%, which was much higher than that achieved in traditional optimization methods. This novel method provided a simple and practical approach for developing miniature ion trap mass analyzer with high performance.

Key words:

1. [1]
  OUYANG Z, COOKS R G.Annu. Rev. Anal. Chem., 2009, 2:187-214.
2. [2]
  GIANNOUKOS S, BRKIC B, TAYLOR S, FRANCE N. J. Am. Soc. Mass Spectrom., 2015, 26(2):231-239.
3. [3]
  JIANG P H, ZHOU Z Q, WU Z J, ZHAO Z F. Instrum. Sci. Technol., 2018, 46(6):614-627.
4. [4]
  ZHANG W, WANG X, XIA Y, OUYANG Z. Theranostics, 2017, 7(12):2968-2981.
5. [5]
  JANFELT C, GRAESBOLL R, LAURITSEN F R. Int. J. Environ. Anal. Chem., 2012, 92(4):397-404.
6. [6]
  LIU Rui, LYU Yi. Spectrosc. Spectral Anal., 2019, 39(5):1346-1353. 刘睿, 吕弋. 光谱学与光谱分析, 2019, 39(5):1346-1353.
7. [7]
  CHANDRA D, GAYATHRI P, VATS M, NAGARAJ R, JAGANNADHAM M V. Eur. J. Mass Spectrom., 2020, 26(1):36-45.
8. [8]
  BRINCKERHOFF W B. Appl. Phys. A:Mater. Sci. Process., 2004, 79(4-6):953-956.
9. [9]
  SCHWARTZ J C, SENKO M W, SYKA J E P. J. Am. Soc. Mass Spectrom., 2002, 13(6):659-669.
10. [10]
  STAFFORD G. J. Am. Soc. Mass Spectrom., 2002, 13(6):589-596.
11. [11]
  WELLS J M, BADMAN E R, COOKS R G. Anal. Chem., 1998, 70(3):438-444.
12. [12]
  COLLINGS B A. Rapid Commun. Mass Spectrom., 2011, 25(1):66-74.
13. [13]
  SUN Lu-Lu, XU Chong-Sheng, XU Fu-Xing, ZHOU Zhen, DING Chuan-Fan. Chin. J. Anal. Chem., 2018, 46(12):1872-1877. 孙露露, 许崇晟, 徐福兴, 周振, 丁传凡. 分析化学, 2018, 46(12):1872-1877.
14. [14]
  CHEN Xin, GU Lian-Cheng, XU Fu-Xing, FANG Xiang, CHU Yan-Qiu, XIAO Yu, ZHOU Ming-Fei, DING Chuan-Fan. Chin. J. Anal. Chem., 2019, 47(8):1145-1152. 陈新, 古连城, 徐福兴, 方向, 储艳秋, 肖育, 周鸣飞, 丁传凡.分析化学, 2019, 47(8):1145-1152.
15. [15]
  OUYANG Z, WU G X, SONG Y S, LI H Y, PLASS W R, COOKS R G. Anal. Chem., 2004, 76(16):4595-4605.
16. [16]
  LI X X, JIANG G Y, LUO C, XU F X, WANG Y Y, DING L, DING C F. Anal. Chem., 2009, 81(12):4840-4846.
17. [17]
  SUDAKOV M Y, APATSKAYA M V, VITUKHIN V V, TRUBITSYN A A. J. Anal. Chem., 2012, 67(14):1057-1065.
18. [18]
  DOUGLAS D J, KONENKOV N V. Rapid Commun. Mass Spectrom., 2014, 28(21):2252-2258.
19. [19]
  ZHANG Y J, WU H Y, YAO R J, QIAN J, GE S J, M Q, BAI H, XIAO Y, LI X X. Rapid Commun. Mass Spectrom., 2020, 34(9):e18371.
20. [20]
  YAO Ru-Jiao, DING Zheng-Zhi, JING Jia-Rong, QI Xiao-Jun, ZHU Yong-Yong, PANG Jun-De, JIANG Gong-Yu, XIAO Yu. Chin. J. Anal. Chem., 2020, 48(4):463-472. 姚如娇, 丁正知, 景加荣, 齐晓军, 朱勇勇, 庞骏德, 蒋公羽, 肖育. 分析化学, 2020, 48(4):463-472.
21. [21]
  GOERINGER D E, WHITTEN W B, RAMSEY J M, MCLUCKEY S A, GLISH G L. Anal. Chem., 1992, 64(13):1434-1439.
22. [22]
  SUDAKOV M, KONENKOV N, DOUGLAS D J, GLEBOVA T. J. Am. Soc. Mass Spectrom., 2000, 11(1):10-18.
23. [23]
  SNYDER D T, COOKS R G. Anal. Chem., 2017, 89(15):8148-8155.
24. [24]
  JIANG T, XU Q, ZHANG H J, LI D Y, XU W. Anal. Chem., 2018, 90(19):11671-11679.
25. [25]
  FISCHER E Z. Zeitschrift Für Physik, 1959, 156(1):1-26.
26. [26]
  JIANG D, JIANG G Y, LI X X, XU F X, WANG L, DING L, DING C F. Anal. Chem., 2013, 85(12):6041-6046.
27. [27]
  HE Yang, YAO Ru-Jiao, XIAO Yu, YUAN Guang-Zhou, ZHANG Zai-Yue, DING Chuan-Fan, LI Xiao-Xu. J. Chin. Mass Spectrom. Soc., 2017, 38(3):265-271. 何洋, 姚如娇, 肖育, 袁广洲, 张在越, 丁传凡, 李晓旭. 质谱学报, 2017, 38(3):265-271.
28. [28]
  SUDAKOV M Y, APATSKAYA M V, VITUKHIN V V, TRUBITSYN A A. J. Anal. Chem., 2012, 67(14):1057-1065.
29. [29]
  CHATTOPADHYAY M, MOHANTY A K. Int. J. Mass Spectrom., 2010, 295(1-2):49-59.
30. [30]
  REMES P M, SYKA J E P, KOVTOUN V V, SCHWARTZ J C. Int. J. Mass Spectrom., 2014, 370:44-57.
31. [31]
  WANG Y Z, HUANG Z J, JIANG Y, XIONG X C, DENG Y L, FANG X, XU W. J. Mass Spectrom., 2013, 48(8):937-944.
32. [32]
  SNYDER D T, PENG W P, COOKS R G. Chem. Phys. Lett., 2017, 668:69-89.
33. [33]
  DELAHAYE P. Eur. Phys. J. A, 2019, 55(5):83.
34. [34]
  WU H F, CHEN L W, LIN Y P. J. Chin. Chem. Soc., 1999, 46(6):923-932.
35. [35]
  SCHWARTZ J C, SYKA J E P, JARDINE I. J. Am. Soc. Mass Spectrom., 1991, 2(3):198-204.

扫一扫看文章

计量

PDF下载量: 7
文章访问数: 1119
HTML全文浏览量: 249

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

印刷电路板离子阱偶极共振激发电场的理论模拟及性能优化

通讯作者: 肖育,E-mail:xxli@suda.edu.cn; 李晓旭,E-mail:xiaoyush812@126.com

English

Optimization of Resonant Excitation Electric Field in Discrete Electrode Printed Circuit Board Ion Trap Mass Analyzer

Corresponding author: XIAO Yu, ; LI Xiao-Xu,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

印刷电路板离子阱偶极共振激发电场的理论模拟及性能优化

通讯作者: 肖育,E-mail:xxli@suda.edu.cn; 李晓旭,E-mail:xiaoyush812@126.com

English

Optimization of Resonant Excitation Electric Field in Discrete Electrode Printed Circuit Board Ion Trap Mass Analyzer

Corresponding author: XIAO Yu, ; LI Xiao-Xu,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs