<i>β</i>-淀粉样蛋白的分析检测方法研究进展

引用本文: 蒋萌, 王晓英, 王小兵. β-淀粉样蛋白的分析检测方法研究进展[J]. 分析化学, 2018, 46(9): 1339-1349. doi: 10.11895/j.issn.0253-3820.171119 shu

Citation: JIANG Meng, WANG Xiao-Ying, WANG Xiao-Bing. Advances in Detection Methods of β-Amyloid Protein[J]. Chinese Journal of Analytical Chemistry, 2018, 46(9): 1339-1349. doi: 10.11895/j.issn.0253-3820.171119 shu

β-淀粉样蛋白的分析检测方法研究进展

1.
环境医学工程教育部重点实验室, 东南大学公共卫生学院, 南京 210009;
2.
天然药化教研室, 中国药科大学中药学院, 南京 210009
基金项目:
本文系国家自然科学基金项目（Nos.81573313，81302472）和江苏省高校"青蓝工程"资助

摘要: 阿尔兹海默症（AD）是一种神经退行性疾病，发病机制目前尚不明确。β-淀粉样蛋白（Aβ）是AD的特异性生物标志物之一，众多临床研究提示血液、脑脊液和脑组织内的Aβ水平异常与AD的病程进展密切相关。Aβ的分析评估对AD早期发现、跟踪、预防和治疗具有重要意义。本文就目前国内外Aβ的常用检测方法进行了概述和比较，重点阐述新型电化学生物传感方法在检测Aβ方面的相关应用及其最新研究进展，并对Aβ电化学传感技术的未来发展提出展望。

关键词:

English

Advances in Detection Methods of β-Amyloid Protein

1.
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China;
2.
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
Received Date: 21 July 2017
Revised Date: 05 June 2018
Fund Project:
This work was supported by the National Natural Science Foundation of China(Nos. 81573313, 81302472) and the "Blue Project" Funded by Universities in Jiangsu Province of China.

Abstract: Alzheimer's disease (AD) is a neurodegenerative disease with unknown etiology. Beta-amyloid protein (Aβ) is one of the specific biomarkers of AD, and many clinical studies suggest that abnormal levels of Aβ in blood, cerebrospinal fluid and brain tissue are closely related to the progression of AD. The analysis and evaluation of Aβ is important for early detection, tracking, prevention and treatment of AD. In this paper, the present situation of the commonly used detection methods of Aβ at home and abroad was summarized and compared. Specifically, the latest application of new electrochemical biosensor in Aβ detection was mainly described, and the summary of its future directions and the potential applications was given. It is intended to provide reference for the further research and application of Aβ.

Key words:

1. [1]
  Hardy J A, Higgins G A. Science,1992,256(5054):184-185
2. [2]
  Claeysen S, Bockaert J, Giannoni P. ACS Chem. Neurosci.,2015,6(7):940-943
3. [3]
  Laferla F M, Green K N, Oddo S. Nat. Rev. Neurosci.,2007,8(7):499-509
4. [4]
  Zhou Y L, Liu L T, Hao Y Q, Xu M T. Chem. Asian J.,2016,11(6):805-817
5. [5]
  Li C Z, Grajales S, Shuang S M, Dong C, Nair M. J. Anal. Test,2017,1(2):15
6. [6]
  Scarano S, Lisi S, Ravelet C, Peyrin E, Minunni M. Anal. Chim. Acta,2016,940:21-37
7. [7]
  Kaushik A, Jayant R D, Tiwari S, Vashist A, Nair M. Biosens. Bioelectron.,2016,80:273-287
8. [8]
  Xia N, Chang Y, Hao Y Q. Int. J. Electrochem. Sci.,2017,12(7):6255-6265
9. [9]
  Wadghiri Y Z, Sigurdsson E M, Sadowski M, Elliott J I, Li Y, Scholtzova H, Tang C Y, Aguinaldo G, Pappolla M, Duff K, Wisniewski T, Turnbull D H. Magnet. Reson. Med.,2003,50(2):293-302
10. [10]
  Raymond S B, Treat L H, Dewey J D, McDannold N J, Hynynen K, Bacskai B J. PLOS One,2008,3(5):e2175
11. [11]
  Gupta S, Babu P, Surolia A. Biomaterials,2010,31(26):6809-6822
12. [12]
  Zhang X L, Tian Y L, Li Z, Tian X Y, Sun H B, Liu H, Moore A, Ran C Z. J. Am. Chem. Soc.,2013,135(44):16397-16409
13. [13]
  Zhang X L, Tian Y L, Zhang C, Tian X Y, Ross A W, Moir R D, Sun H B, Tanzi R E, Moore A, Ran C Z. Proc. Natl. Acad. Sci.USA,2015,112(31):9734-9739
14. [14]
  Smith S V. J. Inorg. Biochem.,2004,98(11):1874-1901
15. [15]
  Zhou Y L, Dong H, Liu L T, Xu M T. Small,2015,11(18):2144-2149
16. [16]
  Deng C Y, Liu H, Zhang M M, Deng H H, Lei C Y, Shen L, Jiao B, Tu Q Y, Jin Y, Xiang L, Deng W, Xie Y F, Xiang J. Anal. Chem.,2018,90(3):1710-1717
17. [17]
  Hülsemann M, Zafiu C, Kühbach K, Lühmann N, Herrmann Y, Peters L, Linnartz C, Willbold J, Kravchenko K, Kulawik A, Willbold S, Bannach O, Willbold D. J. Alzheimers Dis.,2016,54(1):79-88
18. [18]
  Kühbach K, Hülsemann M, Herrmann Y, Kravchenko K, Kulawik A, Linnartz C, Peters L, Wang K, Willbold J, Willbold D, Bannach O. Front. Neurosci.,2016,10:8
19. [19]
  Haes A J, Chang L, Klein W L, van Duyne R P. J. Am. Chem. Soc.,2005,127(7):2264-2271
20. [20]
  Xia N, Liu L, Harrington M G, Wang J X, Zhou F M. Anal. Chem.,2010, 82(24):10151-10157
21. [21]
  Wang C K, Liu D J, Wang Z X. Chem. Commun.,2012,48(67):8392-8394
22. [22]
  Yu L, Zhang Y T, Chen R, Zhang D H, Wei X H, Chen F, Wang J X, Xu M T. Talanta,2015,131:475-479
23. [23]
  Xia N, Zhou B B, Huang N B, Jiang M S, Zhang J B, Liu L. Biosens. Bioelectron.,2016,85:625-632
24. [24]
  Demeritte T, Nellore B P V, Kanchanapally R, Sinha S S, Pramanik A, Chavva S R, Ray P C. ACS Appl. Mater. Interfaces,2015,7(24):13693-13700
25. [25]
  Jiang L F, Chen B C, Chen B, Li X J, Liao H L, Huang H M, Guo Z J, Zhang W Y, Wu L. Talanta,2017,170:350-357
26. [26]
  Liu L, Chang Y, Yu J, Jiang M S, Xia N. Sens. Actuators B,2017,251:359-365
27. [27]
  Esparza T J, Zhao H Z, Cirrito J R, Cairns N J, Bateman R J, Holtzman D M, Brody D L. Ann. Neurol.,2013,73(1):104-119
28. [28]
  Bruggink K A, Jongbloed W, Biemans E A, Veerhuis R, Claassen J A, Kuiperij H B, Verbeek M M. Anal. Biochem.,2013,433(2):112-120
29. [29]
  Hu T, Lu S S, Chen C X, Sun J, Yang X R. Sens. Actuators B,2017,243:792-799
30. [30]
  Kim J A, Kim M, Kang S M, Lim K T, Kim T S, Kang J Y. Biosens. Bioelectron.,2015,67:724-732
31. [31]
  Pi J L, Long Y J, Huang N, Cheng Y, Zheng H Z. Talanta,2016,146, 10-15
32. [32]
  Gagni P, Sola L, Cretich M, Chiari M. Biosens. Bioelectron.,2013,47:490-495
33. [33]
  Ammar M, Smadja C, Giang T P L, Azzouz M, Vigneron J, Etcheberry A, Taverna M, Dufour G E. Biosens. Bioelectron.,2013,40(1):329-335
34. [34]
  Haußmann U, Jahn O, Linning P, Janßen C, Liepold T, Portelius E, Zetterberg H, Bauer C, Schuchhardt J, Kn lker H J, Klafki H, Wiltfang J. Anal. Chem,2013,85(17):8142-8149
35. [35]
  Vestergaard M, Kerman K, Saito M, Nagatani N, Takamura Y, Tamiya E. J. Am. Chem. Soc.,2005,127(34):11892-11893
36. [36]
  Veloso A J, Kerman K. Bioelectrochemistry,2012,84:49-52
37. [37]
  Suprun E V, Radko S P, Khmeleva S A, Mitkevich V A, Archakov A I, Makarov A A, Shumyantseva V V. Electrochem. Commun.,2017,75:33-37
38. [38]
  Enache T A, Oliveira-Brett A M. Bioelectrochemistry,2017,114:13-23
39. [39]
  Zhang L, Kai T H, Sun Z F, Hao Y Q, Tu Q Y, Zhou F M. Electroanalysis,2013,25(7):1659-1664
40. [40]
  El-Said W A, El-Hameed K A, El-Maali N A, Sayyed H G. Electroanalysis,2017,29:748-755
41. [41]
  Prabhulkar S, Piatyszek R, Cirrito J R, Wu Z Z, Li C Z. J. Neurochem.,2012,122(2):374-381
42. [42]
  Li S S, Liu C W, Wei K C, Huang C Y, Hsu P H, Liu H L, Lu Y J, Lin S C, Yang H W, Ma C C. Sci. Rep.,2016,6:25155
43. [43]
  Wu C C, Ku B C, Ko C H, Chiu C C, Wang G J, Yang Y H,Wu S J. Electrochim. Acta,2014,134:249-257
44. [44]
  Lien T T, Takamura Y, Tamiya E, Vestergaard M C. Anal. Chim. Acta,2015,892:69-76
45. [45]
  Carneiro P, Loureiro J, Delerue-Matos C, Morais S, Pereira M D. Sens. Actuators B,2017, 239:157-165
46. [46]
  de la Escosura-Muñiz A, Plichta Z, Horák D, Merkoçi A. Biosens. Bioelectron.,2015,67:162-169
47. [47]
  Liu L, Zhao F, Ma F J, Zhang L P, Yang S L, Xia N. Biosens. Bioelectron.,2013,49:231-235
48. [48]
  Han J, Zhang M F, Chen G J, Zhang Y Q, Wei Q, Zhuo Y, Xie G, Yuan R, Chen S P. J. Mater. Chem. B,2017,5(42):8330-8336
49. [49]
  Rama E C, Gonzalez-Garcia M B, Costa-Garcia A. Sens. Actuators B,2014,201(4):567-571
50. [50]
  Liu L, He Q G, Zhao F, Xia N, Liu H J, Li S J, Liu R L, Zhang H. Biosens. Bioelectron.,2014,51:208-212
51. [51]
  Diba F S, Kim S, Lee H J. Catal. Today,2017,295:41-47
52. [52]
  Wang J X, Zhuo Y, Zhou Y, Wang H J, Yuan R, Chai Y Q. ACS Appl. Mater. Interfaces,2016,8(20):12968-12975
53. [53]
  Beheshti S, Martic S, Kraatz H B. Chemphyschem,2012,13(2):542-548
54. [54]
  Li H, Cao Y, Wu X L, Ye Z H, Li G X. Talanta,2012,93:358-363
55. [55]
  Li H, Xie H N, Cao Y, Ding X R, Yin Y M, Li G X. Anal. Chem.,2013,85(2):1047-1052
56. [56]
  Lauren J, Gimbel D A, Nygaard H B, Gilbert J W, Strittmatter S M. Nature,2009,457(7233):1128-1132
57. [57]
  Xia N, Wang X, Zhou B B, Wu Y Y, Mao W H, Liu L. ACS Appl. Mater. Interfaces,2016,8(30):19303-19311
58. [58]
  Xia N, Wang X, Yu J, Wu Y Y, Cheng S C, Xing Y, Liu L. Sens. Actuators B,2017,239:834-840
59. [59]
  Xing Y, Feng X Z, Zhang L P, Hou J T, Han G C, Chen Z C. Int. J. Nanomed.,2017,12:3171-3179
60. [60]
  Rushworth J V, Ahmed A, Griffiths H H, Pollock N M, Hooper N M, Millner P A. Biosens. Bioelectron.,2014,56:83-90
61. [61]
  Liu L, Xia N, Jiang M S, Huang N B, Guo S, Li S J, Zhang S L. J. Electroanal. Chem.,2015,754:40-45
62. [62]
  Janmey P A. Annu. Rev. Physiol.,1994,56:169-191
63. [63]
  Chauhan V P, Ray I, Chauhan A, Wisniewski H M. Biochem. Bioph. Res. Commun.,1999,258(2):241-246
64. [64]
  Yu Y Y, Sun X Y, Tang D Q, Li C L, Zhang L, Nie D X, Yin X X, Shi G Y. Biosens. Bioelectron.,2015,68:115-121
65. [65]
  Yu Y Y, Zhang L, Li C L, Sun X Y, Tang D Q, Shi G Y. Angew. Chem. Int. Edit.,2014,53(47):12832-12835
66. [66]
  Atamna H, Boyle K. Proc. Natl. Acad. Sci. USA,2006,103(9):3381-3386
67. [67]
  Zhou Y L, Wang J, Liu L T, Wang R R, Lai X H, Xu M T. ACS Chem. Neurosci.,2013,4(4):535-539
68. [68]
  Neumann B, Yarman A, Wollenberger U, Scheller F. Anal. Bioanal. Chem.,2014,406(14):3359-3364
69. [69]
  Pramanik D, Sengupta K, Mukherjee S, Dey S G, Dey A. J. Am. Chem. Soc.,2012,134(29):12180-12189
70. [70]
  Ylera F, Lurz R, Erdmann V A, Fürste J P. Biochem. Biophys. Res. Commun.,2002,290(5):1583-1588
71. [71]
  Takahashi T, Tada K, Mihara H. Mol. Biosyst.,2009,5(9):986-991
72. [72]
  Tsukakoshi K, Abe K, Sode K, Ikebukuro K. Anal. Chem.,2012,84(13):5542-5547
73. [73]
  Zhou Y L, Zhang H Q, Liu L T, Li C M, Chang Z, Zhu X, Ye B X, Xu M T. Sci. Rep.,2016,6:35186
74. [74]
  Ke H, Sha H F, Wang Y F, Guo W W, Zhang X, Wang Z M, Huang C S, Jia N Q. Biosens. Bioelectron.,2018,100:266-273

扫一扫看文章

计量

PDF下载量: 24
文章访问数: 1097
HTML全文浏览量: 129

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

β-淀粉样蛋白的分析检测方法研究进展

English

Advances in Detection Methods of β-Amyloid Protein

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

β-淀粉样蛋白的分析检测方法研究进展

English

Advances in Detection Methods of β-Amyloid Protein

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs