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A cesium fluoride promoted efficient and rapid multicomponent synthesis of functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives

Yogesh B. Wagh ,  Yogesh A. Tayade ,  Swapnil A. Padvi ,  Bhupesh S. Patil ,  Nilesh B. Patil ,  Dipak S. Dalal

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Citation:  Yogesh B. Wagh, Yogesh A. Tayade, Swapnil A. Padvi, Bhupesh S. Patil, Nilesh B. Patil, Dipak S. Dalal. A cesium fluoride promoted efficient and rapid multicomponent synthesis of functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives[J]. Chinese Chemical Letters, 2015, 26(10): 1273-1277. doi: 10.1016/j.cclet.2015.06.014 shu

A cesium fluoride promoted efficient and rapid multicomponent synthesis of functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives

    • 通讯作者: Dipak S. Dalal,
  • 基金项目:

    One of the authors (Y.B.W.) acknowledges UGC, New Delhi for SAP fellowship under the scheme 'Research Fellowship in Sciences for Meritorious Students'. The authors are also grateful to SAIF Panjab University for providing analytical facilities for characterization of compounds. (Y.B.W.)

摘要: A rapid, one-pot and highly efficient protocol for the synthesis of pharmaceutically interesting functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives has been developed using commercially available CsF as a catalyst in the reaction of malononitrile and aryl aldehydes or isatins with 1, 3-cyclohexanediones. The major advantages of this methodology are excellent yield at ambient temperature, very short reaction time (5-10 min), and use of an inexpensive catalyst.

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  • 发布日期:  2015-06-17
  • 收稿日期:  2015-03-13
  • 网络出版日期:  2015-05-18
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