A bestatin-based fl uorescent probe for aminopeptidase N cell imaging

注册 English

A bestatin-based fl uorescent probe for aminopeptidase N cell imaging

Hui Chen , Hui Wang , Xiao-Jun Qin , Chen Chen , Lu Feng , Lai-Zhong Chen , Lu-Pei Du , Min-Yong Li

Citation: Hui Chen, Hui Wang, Xiao-Jun Qin, Chen Chen, Lu Feng, Lai-Zhong Chen, Lu-Pei Du, Min-Yong Li. A bestatin-based fl uorescent probe for aminopeptidase N cell imaging[J]. Chinese Chemical Letters, 2015, 26(5): 513-516. doi: 10.1016/j.cclet.2015.01.023 shu

shu

A bestatin-based fl uorescent probe for aminopeptidase N cell imaging

通讯作者: Min-Yong Li,

基金项目:
The present work was supported by the Program for New Century Excellent Talents in University (No. NCET-11-0306) (No. NCET-11-0306)

ong Natural Science Foundation (No. JQ201019) (No. JQ201019)

ong University, IIFSDU (No. 2014JC008) (No. 2014JC008)

ong University, GIIFSDU (No. yzc12096). (No. yzc12096)

摘要: Aminopeptidase N (APN) is an important drug target and biomarker for various tumors. The current work characterizes a novel APN-targeted fluorescent probe (Bes-Green, 2) that manifests comparable inhibitory activity with Bestatin. This probe has capacity of tightly binding to the APN for imaging endogenous APN in living human ovarian clear cell carcinoma cells (ES-2) and has potential application in biological study of cellular APN.

关键词:

English

A bestatin-based fl uorescent probe for aminopeptidase N cell imaging

1.
a Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan 250012, China;
b China Pharmaceutical University Pharmaceutical Co.
b China Pharmaceutical University Pharmaceutical Co. Ltd., Nanjing 210009, China

Corresponding author: Min-Yong Li,

Received Date: 14 November 2014
Available Online: 28 January 2015
Fund Project:

Abstract: Aminopeptidase N (APN) is an important drug target and biomarker for various tumors. The current work characterizes a novel APN-targeted fluorescent probe (Bes-Green, 2) that manifests comparable inhibitory activity with Bestatin. This probe has capacity of tightly binding to the APN for imaging endogenous APN in living human ovarian clear cell carcinoma cells (ES-2) and has potential application in biological study of cellular APN.

Key words:

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