Synthesis of 2-[2H]-2-(1-methylalkyl)succinic acids

Xin-Yu Bian Serge Maurice Mbadinga Shi-Zhong Yang Ru-Qiang Ye Ji-Dong Gu Bo-Zhong Mua

Citation:  Xin-Yu Bian, Serge Maurice Mbadinga, Shi-Zhong Yang, Ru-Qiang Ye, Ji-Dong Gu, Bo-Zhong Mua. Synthesis of 2-[2H]-2-(1-methylalkyl)succinic acids[J]. Chinese Chemical Letters, 2015, 26(5): 619-622. doi: 10.1016/j.cclet.2015.01.010 shu

Synthesis of 2-[2H]-2-(1-methylalkyl)succinic acids

  • 基金项目:

    This work was supported by the National Natural Science Foundation of China (No. 41373070, 51174092)  (No. 41373070, 51174092)

    the National Natural Science Foundation of China/Research Grants Council Joint Research Fund (No. 41161160560). (No. 41161160560)

摘要: We describe a specific procedure for the synthesis of deuterium-labelled 2-(1-methylalkyl)succinate established via alkylation of diethyl malonate, Krapcho decarboxylation reaction with D2O and hydrolysis reaction. Two novel compounds, 2-[2H]-2-ethylsuccinic acid and 2-[2H]-2-(1-methylheptyl) succinic acid were prepared via this synthetic route and characterized by mass spectrometry and 1H NMR. The results showed that the 2-(1-methylalkyl)succinic acids were deuterated at the β-position, which is considered as an important reaction centre in the anaerobic degradation of n-alkanes.

English

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  • 发布日期:  2015-01-10
  • 收稿日期:  2014-09-17
  • 网络出版日期:  2014-12-25
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