引用本文:
Chun Cui Huang, Hui Bo Shao. Enhanced flow injection analysis for measurements of S-nitrosothiols species in biological samples using highly selective amperometric nitric oxide sensor[J]. Chinese Chemical Letters,
2012, 23(2): 229-232.
doi:
10.1016/j.cclet.2011.11.003
Citation: Chun Cui Huang, Hui Bo Shao. Enhanced flow injection analysis for measurements of S-nitrosothiols species in biological samples using highly selective amperometric nitric oxide sensor[J]. Chinese Chemical Letters, 2012, 23(2): 229-232. doi: 10.1016/j.cclet.2011.11.003

Citation: Chun Cui Huang, Hui Bo Shao. Enhanced flow injection analysis for measurements of S-nitrosothiols species in biological samples using highly selective amperometric nitric oxide sensor[J]. Chinese Chemical Letters, 2012, 23(2): 229-232. doi: 10.1016/j.cclet.2011.11.003

Enhanced flow injection analysis for measurements of S-nitrosothiols species in biological samples using highly selective amperometric nitric oxide sensor
摘要:
A highly selective nitric oxide (NO) sensor is fabricated and applied to devise an enhanced flow injection analysis (FIA) system for S-nitrosothiols (RSNOs) measurement in biological samples. The NO sensor is prepared using a polytetrafluoroethylene (PTFE) gas-permeable membrane loaded with Teflon AF® solution, a copolymer of tetrafluoroethylene and 2, 2-bis(trifluoroethylene)-4, 5-difluoro-1, 3-dioxole, to improve selectivity. This method is much simpler and possesses good performance over a wide range of RSNOs concentrations. Standard deviation for three parallel measurements of blood plasma is 4.0%. The use of the gas sensing configuration as the detector enhances selectivity of the FIA measurement vs. using less selective electrochemical detectors that do not use PTFE/Teflon type outer membranes.
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关键词:
- Enhanced FIA method
- / Plasma
- / RSNOs
- / Highly selective NO sensor
English
Enhanced flow injection analysis for measurements of S-nitrosothiols species in biological samples using highly selective amperometric nitric oxide sensor
Abstract:
A highly selective nitric oxide (NO) sensor is fabricated and applied to devise an enhanced flow injection analysis (FIA) system for S-nitrosothiols (RSNOs) measurement in biological samples. The NO sensor is prepared using a polytetrafluoroethylene (PTFE) gas-permeable membrane loaded with Teflon AF® solution, a copolymer of tetrafluoroethylene and 2, 2-bis(trifluoroethylene)-4, 5-difluoro-1, 3-dioxole, to improve selectivity. This method is much simpler and possesses good performance over a wide range of RSNOs concentrations. Standard deviation for three parallel measurements of blood plasma is 4.0%. The use of the gas sensing configuration as the detector enhances selectivity of the FIA measurement vs. using less selective electrochemical detectors that do not use PTFE/Teflon type outer membranes.
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Key words:
- Enhanced FIA method
- / Plasma
- / RSNOs
- / Highly selective NO sensor

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