引用本文:
Jian Jun Xue, Yu Mei Zhou, Xiao Ming Yu. Preparation of 4-and 6-desphenyl analogues of (-)-clausenamide and alternative synthesis of (+)-epi-clausenamide[J]. Chinese Chemical Letters,
2011, 22(11): 1261-1264.
doi:
10.1016/j.cclet.2011.07.002
Citation: Jian Jun Xue, Yu Mei Zhou, Xiao Ming Yu. Preparation of 4-and 6-desphenyl analogues of (-)-clausenamide and alternative synthesis of (+)-epi-clausenamide[J]. Chinese Chemical Letters, 2011, 22(11): 1261-1264. doi: 10.1016/j.cclet.2011.07.002
Citation: Jian Jun Xue, Yu Mei Zhou, Xiao Ming Yu. Preparation of 4-and 6-desphenyl analogues of (-)-clausenamide and alternative synthesis of (+)-epi-clausenamide[J]. Chinese Chemical Letters, 2011, 22(11): 1261-1264. doi: 10.1016/j.cclet.2011.07.002
Preparation of 4-and 6-desphenyl analogues of (-)-clausenamide and alternative synthesis of (+)-epi-clausenamide
摘要:
4-and 6-desphenyl analogues of (-)-clausenamide, 6 and 7, were prepared in optical active form from commercially available D-pyroglutamic acid and the known racemic pyrrolidinone 13, respectively. In order to confirm the absolute stereochemistry of (+)-and (-)-7, intermediate 19b was transferred into the (+)-epi-clausenamide 8.
English
Preparation of 4-and 6-desphenyl analogues of (-)-clausenamide and alternative synthesis of (+)-epi-clausenamide
Abstract:
4-and 6-desphenyl analogues of (-)-clausenamide, 6 and 7, were prepared in optical active form from commercially available D-pyroglutamic acid and the known racemic pyrrolidinone 13, respectively. In order to confirm the absolute stereochemistry of (+)-and (-)-7, intermediate 19b was transferred into the (+)-epi-clausenamide 8.
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Key words:
- (-)-Clausenainide
- / Desphenyl analogue
- / (+)-epi-Clausenamide
- / Synthesis
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