引用本文:
Fan Zhang, Xin Zhai, Li Juan Chen, Jian Guo Qi, Bo Cui, Yu Cheng Gu, Ping Gong. Synthesis and cytotoxic activity of 2,5-disubstituted pyrimido[5,4-c] quinoline derivatives[J]. Chinese Chemical Letters,
2011, 22(11): 1277-1280.
doi:
10.1016/j.cclet.2011.05.030
Citation: Fan Zhang, Xin Zhai, Li Juan Chen, Jian Guo Qi, Bo Cui, Yu Cheng Gu, Ping Gong. Synthesis and cytotoxic activity of 2,5-disubstituted pyrimido[5,4-c] quinoline derivatives[J]. Chinese Chemical Letters, 2011, 22(11): 1277-1280. doi: 10.1016/j.cclet.2011.05.030
Citation: Fan Zhang, Xin Zhai, Li Juan Chen, Jian Guo Qi, Bo Cui, Yu Cheng Gu, Ping Gong. Synthesis and cytotoxic activity of 2,5-disubstituted pyrimido[5,4-c] quinoline derivatives[J]. Chinese Chemical Letters, 2011, 22(11): 1277-1280. doi: 10.1016/j.cclet.2011.05.030
Synthesis and cytotoxic activity of 2,5-disubstituted pyrimido[5,4-c] quinoline derivatives
摘要:
A series of 2, 5-disubstituted pyrimido[5, 4-c]quinoline derivatives were synthesized and their cytotoxic activity against H460, HT-29 and MDA-MB-231 cell lines was evaluated in vitro. It was found that most of the tested compounds especially compound 17, shown stronger activity to the selected three cell lines than ZM447439.
English
Synthesis and cytotoxic activity of 2,5-disubstituted pyrimido[5,4-c] quinoline derivatives
Abstract:
A series of 2, 5-disubstituted pyrimido[5, 4-c]quinoline derivatives were synthesized and their cytotoxic activity against H460, HT-29 and MDA-MB-231 cell lines was evaluated in vitro. It was found that most of the tested compounds especially compound 17, shown stronger activity to the selected three cell lines than ZM447439.
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Key words:
- Pyrimido[5,4-c]quinoline
- / Synthesis
- / Cytotoxic activity
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