引用本文:
Tarek A. Salama, Saad S. Elmorsy. Silicon mediated synthesis and selected transformations of β-chloroketones[J]. Chinese Chemical Letters,
2011, 22(10): 1171-1174.
doi:
10.1016/j.cclet.2011.05.007
Citation: Tarek A. Salama, Saad S. Elmorsy. Silicon mediated synthesis and selected transformations of β-chloroketones[J]. Chinese Chemical Letters, 2011, 22(10): 1171-1174. doi: 10.1016/j.cclet.2011.05.007
Citation: Tarek A. Salama, Saad S. Elmorsy. Silicon mediated synthesis and selected transformations of β-chloroketones[J]. Chinese Chemical Letters, 2011, 22(10): 1171-1174. doi: 10.1016/j.cclet.2011.05.007
Silicon mediated synthesis and selected transformations of β-chloroketones
摘要:
A combination of tetrachlorosilane (TCS) and phenol in dichloromethane was found to be an efficient reagent for hydro-chlorination of α, β-unsaturated ketones to afford the corresponding β-chloroketones in good yield at ambient temperature. Reactions of the titled compounds with TCS-NaN3 as well as with nitriles utilizing TCS-ZnCl2 to give 1, 5-disubstituted tetrazole derivatives or β-amido ketones respectively are also described.
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关键词:
- Tetrachlorosilane
- / Phenol
- / β-Chloroketones
- / Synthesis
- / Tetrazoles
- / β-Amido ketones
English
Silicon mediated synthesis and selected transformations of β-chloroketones
Abstract:
A combination of tetrachlorosilane (TCS) and phenol in dichloromethane was found to be an efficient reagent for hydro-chlorination of α, β-unsaturated ketones to afford the corresponding β-chloroketones in good yield at ambient temperature. Reactions of the titled compounds with TCS-NaN3 as well as with nitriles utilizing TCS-ZnCl2 to give 1, 5-disubstituted tetrazole derivatives or β-amido ketones respectively are also described.
-
Key words:
- Tetrachlorosilane
- / Phenol
- / β-Chloroketones
- / Synthesis
- / Tetrazoles
- / β-Amido ketones
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